LncRRIsearch: A Web Server for lncRNA-RNA Interaction Prediction Integrated With Tissue-Specific Expression and Subcellular Localization Data
LncRRIsearch: A Web Server for lncRNA-RNA Interaction Prediction Integrated With Tissue-Specific Expression and Subcellular Localization Data
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DOI：
10.3389/fgene.2019.00462
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发表时间：
2019-05-28
影响因子：
3.7
通讯作者：
Hamada, Michiaki
中科院分区：
文献类型：
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作者：
Fukunaga, Tsukasa;Iwakiri, Junichi;Hamada, Michiaki
长链非编码RNA（longnon-codingRNA，lncRNA）在多种生物学过程中发挥着重要作用，但大部分lncRNA的功能尚不清楚。用于估计lncRNA的功能的一种方法是鉴定其相互作用靶标，因为在相当多的情况下lncRNA的功能通过与其他生物分子的相互作用来表达。在本文中，我们开发了“LncRRIsearch”，这是一个Web服务器，用于综合预测人类和小鼠lncRNA-lncRNA和lncRNA-mRNA相互作用。使用Rlblast进行预测，Rlblast是一种快速准确的RNA-RNA相互作用预测工具。用户可以通过网络界面研究特定lncRNA的相互作用靶RNA。此外，我们将lncRNA的组织特异性表达和亚细胞定位数据与网络服务器集成在一起。这些数据使用户能够检查组织特异性或亚细胞局部lncRNA相互作用。LncRRI搜索可在http://rtools.cbrc.jp/LncRRIsearch/上公开访问。
Long non-coding RNAs (lncRNAs) play critical roles in various biological processes, but the function of the majority of lncRNAs is still unclear. One approach for estimating a function of a lncRNA is the identification of its interaction target because functions of lncRNAs are expressed through interaction with other biomolecules in quite a few cases. In this paper, we developed "LncRRIsearch," which is a web server for comprehensive prediction of human and mouse lncRNA-lncRNA and lncRNA-mRNA interaction. The prediction was conducted using Rlblast, which is a fast and accurate RNA-RNA interaction prediction tool. Users can investigate interaction target RNAs of a particular lncRNA through a web interface. In addition, we integrated tissue-specific expression and subcellular localization data for the lncRNAs with the web server. These data enable users to examine tissue-specific or subcellular localized lncRNA interactions. LncRRIsearch is publicly accessible at http://rtools.cbrc.jp/LncRRIsearch/.