Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing
Polyox and carrageenan based composite film dressing containing anti-microbial and anti-inflammatory drugs for effective wound healing
复制标题
DOI：
10.1016/j.ijpharm.2012.11.045
复制
发表时间：
2013-01-30
影响因子：
5.8
通讯作者：
Tetteh, John
中科院分区：
文献类型：
--
作者：
Boateng, Joshua S.;Pawar, Harshavardhan V.;Tetteh, John
聚氧聚乙烯（Polyox）和卡拉胶基溶剂型铸膜已配制成敷料的药物输送到伤口。用甘油塑化的薄膜上装载链霉素（30%,w/w）和双氯芬酸（10%,w/w），以增强慢性伤口的愈合效果。通过织构分析（力学和黏附性能）、扫描电子显微镜、差示扫描量热法、x射线衍射和傅里叶变换红外光谱对空白和载药薄膜进行了表征。此外，还进行了肿胀、体外药物释放和抗菌研究，以进一步表征膜的特性。空白膜和载药膜均表现出光滑、均匀的表面形貌、优异的透明度、高弹性和可接受的拉伸（机械）性能。负载药物的薄膜具有较高的吸收模拟伤口液体的能力和显著的黏附力，有望有效地粘附和保护伤口。该薄膜对链霉素和双氯芬酸均有72小时的控释。与单个药物的抑制区相比，这些载药薄膜对金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌产生了更高的抑制区。联用链霉素可以预防和治疗慢性伤口感染，而双氯芬酸可以针对伤口愈合的炎症期减轻疼痛和肿胀。(C) 2012 Elsevier b.v.版权所有
Polyethylene oxide (Polyox) and carrageenan based solvent cast films have been formulated as dressings for drug delivery to wounds. Films plasticised with glycerol were loaded with streptomycin (30%, w/w) and diclofenac (10%, w/w) for enhanced healing effects in chronic wounds. Blank and drug loaded films were characterised by texture analysis (for mechanical and mucoadhesive properties), scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and Fourier transform infrared spectroscopy. In addition, swelling, in vitro drug release and antibacterial studies were conducted to further characterise the films. Both blank and drug loaded films showed a smooth, homogeneous surface morphology, excellent transparency, high elasticity and acceptable tensile (mechanical) properties. The drug loaded films showed a high capacity to absorb simulated wound fluid and significant mucoadhesion force which is expected to allow effective adherence to and protection of the wound. The films showed controlled release of both streptomycin and diclofenac for 72 h. These drug loaded films produced higher zones of inhibition against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli compared to the individual drugs zones of inhibition. Incorporation of streptomycin can prevent and treat chronic wound infections whereas diclofenac can target the inflammatory phase of wound healing to relieve pain and swelling. (C) 2012 Elsevier B. V. All rights reserved.