Mesolimbic dopaminergic system activity as a function of food reward: A microdialysis study
Mesolimbic dopaminergic system activity as a function of food reward: A microdialysis study
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DOI：
10.1016/0091-3057(95)00187-5
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发表时间：
1996-01-01
影响因子：
3.6
通讯作者：
Fantino, M
中科院分区：
文献类型：
--
作者：
Martel, P;Fantino, M
中脑边缘多巴胺能系统（MDS）已被证明与摄食行为有关。本实验旨在研究食物的感官特性对MDS活性的影响。采用微透析-高效液相色谱-电化学检测法测定了自由活动大鼠延髓外侧核内多巴胺（DA）及其主要代谢产物（DOPAC和HVA）的含量。在微透析会议期间，大鼠有机会或没有不同的适口性粉末状食物：高适口性（HP）的食物和低适口性（LP）的食物，经常吃蛋糕。在没有食物的情况下，DA，DOPAC和HVA的细胞外水平没有变化。在饲养过程中，DA显着上升，更大的上升为HP比LP食品。DOPAC和HVA的水平仅在HP食物中达到显著性。结果表明，MDS在食物摄入时被激活，并表明MDS活性与食物的奖励性质有关。
The mesolimbic dopaminergic system (MDS) has been shown to be implicated in feeding behaviors. The present experiment was conducted to examine the effects of the sensory properties of food ingested on MDS activity. Microdialysis coupled to high-performance liquid chromatography with electrochemical detection was employed to measure the extracellular levels of dopamine (DA) and its main metabolites (DOPAC and HVA) in the nucleus accumbens of freely moving rats. During microdialysis sessions rats had access or not to powdered foods varying in palatability: short cakes as highly palatable (HP) food and regular chow as low palatable (LP) food. In the absence of food, there were no alterations in extracellular levels of DA, DOPAC, and HVA. During feeding, DA rose significantly with a greater rise for the HP than the LP food. Levels of DOPAC and HVA only reached significance with the HP food. The results indicate that the MDS is activated on ingestion of food, and suggest that MDS activity is related to the rewarding properties of foods.ds