Response to Phenelzine Among Depressed Patients With Features of Hysteroid Dysphoria
Response to Phenelzine Among Depressed Patients With Features of Hysteroid Dysphoria
复制标题
具有子宫内膜异位症特征的抑郁症患者对苯乙肼的反应
DOI：
10.1176/ajp.142.4.486
复制
发表时间：
1985
影响因子：
17.7
通讯作者：
D. Howard
中科院分区：
文献类型：
--
作者：
A. Kayser;D. Robinson;A. Nies;D. Howard
对51例抑郁症门诊患者进行了21项问卷调查。在47名完成了为期6周的双盲研究的患者中，比较了阿米替林和苯乙肼的疗效，14名患者的问卷评分大于或等于13（高分），33名患者的评分小于13（低分）。九分之九的高分患者对苯乙肼有反应;五分之三的高分患者对阿米替林有反应。低评分患者对两种药物的反应同样良好（79%改善）。这些结果表明，一些抑郁症患者的功能，类焦虑不安，这些患者优先响应苯乙肼。
: A 21-item questionnaire eliciting features of hysteroid dysphoria was administered to 51 depressed outpatients. Of the 47 patients who completed a 6-week double-blind study comparing the efficacy of amitriptyline and phenelzine, 14 had questionnaire scores greater than or equal to 13 (high score) and 33 had scores less than 13 (low score). Nine of nine high-score patients responded to phenelzine; only three of five high-score patients responded to amitriptyline. Low-score patients responded equally well to either drug (79% improved). These findings suggest that some depressed patients have features of hysteroid dysphoria and that these patients respond preferentially to phenelzine.