The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity.
The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity.
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DOI：
10.1016/j.neuron.2015.10.049
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发表时间：
2015-12-16
期刊：
影响因子：
16.2
通讯作者：
Davis GW
中科院分区：
文献类型：
--
作者：
Harris N;Braiser DJ;Dickman DK;Fetter RD;Tong A;Davis GW
现在人们认识到大脑具有免疫活性。高度保守的先天免疫信号对病原体入侵和损伤做出反应，并促进神经回路的结构细化。然而，在没有病原体且不考虑细胞损伤或发育变化的情况下，先天免疫信号在神经功能的日常调节过程中是否发挥作用仍然普遍未知。在这里，我们表明先天免疫受体是肽聚糖模式识别受体家族（PGRP-LC）的成员，它是诱导和持续表达稳态突触可塑性所必需的。该受体在突触前发挥作用，在抑制突触后谷氨酸受体功能后控制易于释放的突触小泡池的稳态调节。因此，PGRP-LC 是逆行跨突触信号传导的候选受体，是先天免疫信号传导的新活性，也是任何生物体神经系统中 PGRP 型受体的第一个已知功能。
It is now appreciated that the brain is immunologically active. Highly conserved innate immune signaling responds to pathogen invasion and injury and promotes structural refinement of neural circuitry. However, it remains generally unknown whether innate immune signaling has a function during the day-to-day regulation of neural function in the absence of pathogens and irrespective of cellular damage or developmental change. Here we show that an innate immune receptor, a member of the peptidoglycan pattern recognition receptor family (PGRP-LC), is required for the induction and sustained expression of homeostatic synaptic plasticity. This receptor functions presynaptically, controlling the homeostatic modulation of the readily releasable pool of synaptic vesicles following inhibition of postsynaptic glutamate receptor function. Thus, PGRP-LC is a candidate receptor for retrograde, trans-synaptic signaling, a novel activity for innate immune signaling and the first known function of a PGRP-type receptor in the nervous system of any organism.