Twist induces epithelial-mesenchymal transition in cervical carcinogenesis by regulating the TGF-β/Smad3 signaling pathway
Twist induces epithelial-mesenchymal transition in cervical carcinogenesis by regulating the TGF-β/Smad3 signaling pathway
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Twist 通过调节 TGF-β/Smad3 信号通路诱导宫颈癌发生中的上皮间质转化
DOI：
10.3892/or.2015.4143
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发表时间：
2015-10-01
期刊：
影响因子：
4.2
通讯作者：
Bao, Wei
中科院分区：
文献类型：
--
作者：
Fan, Qiong;Qiu, Met-Ting;Bao, Wei
上皮间质转化（EMT）与宫颈癌的转移和不良预后有关。然而，基本机制的定义很差。在本研究中，我们调查是否扭曲发挥了直接作用，在人类宫颈癌的免疫组化和蛋白质印迹分析。免疫组化分析显示Twist在宫颈癌中高表达，与宫颈癌的病理分化程度和淋巴结转移有关（P
Epithelial-mesenchymal transition (EMT) is associated with the metastasis and poor prognosis of cervical cancer. However, the underlying mechanisms are poorly defined. In the present study, we investigated whether Twist plays a direct role in human cervical cancer using immunohistochemical and western blot analyses. Immunohistochemical analysis revealed that Twist is highly expressed in cervical cancer, which correlates with poor tumor pathological differentiation or lymph node metastasis (P