Increased values of mean platelet volume and platelet size deviation width may provide a safe positive diagnosis of idiopathic thrombocytopenic purpura
Increased values of mean platelet volume and platelet size deviation width may provide a safe positive diagnosis of idiopathic thrombocytopenic purpura
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DOI：
10.1159/000135658
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Alexiou-Daniel, Stiliani
中科院分区：
文献类型：
--
作者：
Ntaios, George;Papadopoulos, Athanasios;Alexiou-Daniel, Stiliani
最近有研究表明，血小板平均体积（MPV）、血小板大小偏差宽度（PDW）和血小板与大细胞比值（P-LCR）等血小板指标有助于鉴别特发性血小板减少性紫癜（ITP）等高破坏性血小板减少症和低生成性血小板减少症（HT）。本研究的目的是评估这些指标在ITP与其他血小板减少症鉴别中的可靠性。方法：我们招募了134例血小板减少患者（男性69例，女性65例），根据基础疾病分为两组：I组（n = 63）包括ITP患者，而II组（n = 71）包括血液学恶性肿瘤化疗后继发骨髓抑制的HT患者。血小板指数来源于Sysmex自动细胞计数器。计算敏感性、特异性、阳性预后值、阴性预后值、效率及约登指数。结果：MPV和PDW指标诊断ITP的敏感性、特异性、阳性预后值、阴性预后值、效率及约登指数均为100%。相反，P-LCR值显著降低。结论：MPV和PDW对ITP的诊断是可靠的。MPV和PDW优于P-LCR。版权所有2008 S. Karger AG，巴塞尔
Introduction: It has been shown recently that platelet indices like mean platelet volume (MPV), platelet size deviation width (PDW) and platelet-to-large-cell ratio (P-LCR) are helpful in the discrimination between hyperdestructive thrombocytopenia like idiopathic thrombocytopenic purpura (ITP) and hypoproductive thrombocytopenia (HT). The aim of the study is to assess the reliability of these indices in the differentiation of ITP from other thrombocytopenias. Methods: We recruited 134 thrombocytopenic patients (69 men, 65 women) who were divided into two groups according to the underlying disease: group I (n = 63) included ITP patients, whereas group II (n = 71) included patients with HT due to myelosuppression secondary to chemotherapy for hematological malignancies. Platelet indices were derived from a Sysmex automated cell counter. Sensitivity, specificity, positive prognostic value, negative prognostic value, efficiency and Youden index were calculated. Results: Concerning MPV and PDW indices, sensitivity, specificity, positive prognostic value, negative prognostic value, efficiency and Youden index were 100% for the diagnosis of ITP. On the contrary, the values for P-LCR were significantly lower. Conclusions: MPV and PDW can be safely relied on for a positive diagnosis of ITP. MPV and PDW were superior to P-LCR. Copyright (C) 2008 S. Karger AG, Basel.