The ISG15/USP18 ubiquitin-like pathway (ISGylation system) in Hepatitis C Virus infection and resistance to interferon therapy
The ISG15/USP18 ubiquitin-like pathway (ISGylation system) in Hepatitis C Virus infection and resistance to interferon therapy
复制标题
DOI：
10.1016/j.biocel.2011.06.006
复制
发表时间：
2011-10-01
影响因子：
4
通讯作者：
McGilvray, Ian
中科院分区：
文献类型：
--
作者：
Chen, Limin;Li, Shilin;McGilvray, Ian
ISG15/USP18 通路调节细胞功能，对于宿主对丙型肝炎病毒 (HCV) 等慢性病毒感染的先天免疫反应非常重要。干扰素刺激基因 15 (ISG15) 是第一个被鉴定的类泛素蛋白修饰剂。就像泛素化一样。 ISG15 通过激活 E1、缀合 E2 和连接 E3 酶的连续酶促作用与靶蛋白缀合（ISGylation）。 ISGylation 调节信号转导途径和宿主抗病毒反应。 ISGylation 过程通过 ISG15 蛋白酶 USP18 的作用是可逆的。泛素样特异性蛋白酶 18 (USP18) 具有 ISG15 依赖和 ISG15 独立的功能；对干扰素治疗无反应的患者肝组织中 ISG15 和 USP18 水平升高的一致发现说明了 ISG15/USP18 通路对慢性 HCV 感染的重要性。机械地。 HCV 似乎利用 ISG15/USP18 途径促进病毒复制并逃避先天抗病毒免疫反应。 (C) 2011 Elsevier Ltd. 保留所有权利。
The ISG15/USP18 pathway modulates cellular functions and is important for the host innate immune response to chronic viral infections such as Hepatitis C Virus (HCV). Interferon stimulated gene 15 (ISG15) was the first ubiquitin-like protein modifier identified. As in ubiquitination. ISG15 conjugates to target proteins (ISGylation) through the sequential enzymatic action of activating E1, conjugating E2, and ligat ing E3 enzymes. ISGylation modulates signal transduction pathways and host anti-viral response. The ISGylation process is reversible through the action of an ISG15 protease, USP18. Ubiquitin-like specific protease 18 (USP18) has functions that are both ISG15-dependent and ISG15-independent; the importance of the ISG15/USP18 pathway to chronic HCV infection is illustrated by the consistent finding of increased levels of ISG15 and USP18 in the liver tissue of patients who do not respond to interferon-based treatments. Mechanistically. HCV seems to exploit the ISG15/USP18 pathway to promote viral replication and evade innate anti-viral immune responses. (C) 2011 Elsevier Ltd. All rights reserved.