K-carrageenan/chitosan nanolayered coating for controlled release of a model bioactive compound
K-carrageenan/chitosan nanolayered coating for controlled release of a model bioactive compound
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DOI：
10.1016/j.ifset.2012.06.004
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发表时间：
2012-10-01
影响因子：
6.6
通讯作者：
Vicente, Antonio A.
中科院分区：
文献类型：
--
作者：
Pinheiro, Ana C.;Bourbon, Ana I.;Vicente, Antonio A.
由K-卡拉胶，硫酸化的阴离子多糖，和壳聚糖，阳离子多糖，通过逐层沉积的多层纳米涂层。将模型阳离子化合物亚甲基蓝（MB）掺入纳米涂层的不同位置，并评价其负载和释放行为。UV-VIS光谱和石英晶体微天平分析显示，MB的负载量随着与第一层的距离而增加，表明MB能够扩散到K-卡拉胶/壳聚糖纳米层涂层中，并且不仅粘附到其正下方的层的表面。MB从K-卡拉胶/壳聚糖纳米涂层的释放成功地用线性叠加模型描述，这使得可以得出结论，MB传输是由于浓度梯度和纳米层的聚合物弛豫。然而，取决于温度和pH值的介质和位置的MB纳入nanolayered涂层，不同的机制prevailed.Industrial相关性：开发新的可食用涂层与改进的功能和性能，例如新鲜和最低限度的加工水果是收获后行业的挑战之一。本工作有助于理解纳米结构中的负载和释放现象，这对于开发应用于食品工业的生物活性化合物释放系统是有用的。此外，K-卡拉胶/壳聚糖纳米涂层代表了一个很有前途的平台，从该平台可以探索不同生物活性化合物的控制释放。(C)2012爱思唯尔有限公司保留所有权利。
Multilayer nanocoatings composed of K-carrageenan, a sulphated anionic polysaccharide, and chitosan, a cationic polysaccharide, were produced by layer-by-layer deposition. The model cationic compound Methylene Blue (MB) was incorporated in different positions of the nanolayered coating and its loading and release behavior was evaluated. UV-VIS spectroscopy and quartz crystal microbalance analysis showed that the amount of MB loaded increased with the distance from the first layer, suggesting that the MB was able to diffuse into the K-carrageenan/chitosan nanolayered coating and not only adhered to the surface of the layer immediately below it. For most of the tested conditions, the MB release from the K-carrageenan/chitosan nanolayered coatings was successfully described by the linear superimposition model, which allowed concluding that MB transport is due to both concentration gradient and the polymer relaxation of the nanolayers. However, depending on temperature and pH of the medium and on the position of MB incorporated on the nanolayered coatings, different mechanisms prevail.Industrial relevance: The development of novel edible coatings with improved functionality and performance for e.g. fresh and minimally processed fruits is one of the challenges of the post-harvest industry. This work contributes to the understanding of the loading and release phenomena involved in structures at the nanoscale, which is useful for the development of bioactive compounds release systems for application in food industry. Moreover, the K-carrageenan/chitosan nanolayered coatings represent a promising platform from which the controlled release of different bioactive compounds may be explored. (C) 2012 Elsevier Ltd. All rights reserved.