Immune recognition of influenza hemagglutinin as a viral and a neo-self-antigen.
Immune recognition of influenza hemagglutinin as a viral and a neo-self-antigen.
复制标题
流感血凝素的免疫识别为病毒和新自身抗原。
DOI：
10.1007/bf02786427
复制
发表时间：
1998
影响因子：
4.4
通讯作者：
Shih,FF
中科院分区：
文献类型：
--
作者：
Caton,AJ;Cerasoli,DM;Shih,FF
为了分析对自身抗原的耐受性和自身免疫的机制，我们产生了表达流感病毒PR 8血凝素（HA）作为新自身抗原的转基因小鼠谱系。通过比较HA Tg小鼠中可诱导的HA特异性T和B细胞应答与非Tg（BALB/c）小鼠中诱导的HA特异性T和B细胞应答，检查了诱导对HA耐受性的特异性和遗传基础。本文总结了使用HA Tg小鼠谱系的研究，这些小鼠在SV 40启动子/增强子的控制下表达不同形式和数量的HA。我们的研究已经揭示了HA特异性T和B细胞的特定亚群从HA Tg小鼠的主要库中被负选择。然而，HA特异性T和B细胞的大量群体逃避阴性选择并且可以通过病毒免疫激活。了解这些自身反应性淋巴细胞分化和参与抗原特异性免疫反应的能力，将提供重要的见解机制，其中自身免疫可能是由病毒轴承与自身抗原的结构相似性诱导。
To analyze mechanisms governing tolerance and autoimmunity to self-antigens, we have generated lineages of transgenic mice that express the influenza virus PR8 hemagglutinin (HA) as a neo-selfantigen. By comparing the HA-specific T and B cell responses that can be induced in HA Tg mice with those that are induced in non-Tg (BALB/c) mice, the specificity and genetic basis with which tolerance is induced to the HA has been examined. This article summarizes studies using lineages of HA Tg mice that express different forms and amounts of the HA under the control of the SV40 promoter/enhancer. Our studies have revealed that specific subsets of HA-specific T and B cells are negatively selected from the primary repertoires of HA Tg mice. However, substantial populations of HA-specific T and B cells evade negative selection and can be activated by virus immunization. Understanding the capacity of these autoreactive lymphocytes to differentiate and participate in antigenspecific immune responses will provide important insights into mechanisms by which autoimmunity might be induced by viruses bearing structural similarities with self-antigens.