Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010-2011 winter season in Japan
Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010-2011 winter season in Japan
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DOI：
10.1099/vir.0.037572-0
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发表时间：
2012-03-01
影响因子：
3.8
通讯作者：
Kida, Hiroshi
中科院分区：
文献类型：
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作者：
Sakoda, Yoshihiro;Ito, Hiroshi;Kida, Hiroshi
H5N1高致病性禽流感病毒(HPAIV)在2010-2011年冬季在日本再次引入并导致鸡只暴发，自2007年HPAI暴发以来一直没有出现高致病性禽流感(HPAI)，并得到控制。2010年10月14日，在日本北海道最北端的大沼湖，从从西伯利亚筑巢湖泊飞出的鸭子的粪便样本中分离到H5N1高致病性禽流感病毒。自那时以来，在日本，已从17个县的63只野鸟中分离出H5N1高致病性禽流感病毒，并于2011年3月底在9个县的24个养鸡场引起高致病性禽流感暴发。这些分离株与奥努马湖的HPAIV分离株以及中国、蒙古、俄罗斯和韩国的HPAIV分离株在基因上都有密切的亲缘关系，属于2.3.2.1遗传支系。此外，这些分离株在基因上被分为三个组，这表明这些病毒是由候鸟通过至少三条不同的路线从它们的北部领土传播到日本的。这些分离株都是抗原性变异株，这与家禽在疫苗诱导的免疫压力下的选择是一致的。为了防止病毒在西伯利亚夏季水鸟筑巢的湖泊中持续存在，在HPAI尚未得到控制的亚洲国家，迫切需要迅速根除家禽中的HPAIV。
H5N1 highly pathogenic avian influenza virus (HPAIV) was reintroduced and caused outbreaks in chickens in the 2010-2011 winter season in Japan, which had been free from highly pathogenic avian influenza (HPAI) since 2007 when HPAI outbreaks occurred and were controlled. On 14 October 2010 at Lake Ohnuma, Wakkanai, the northernmost part of Hokkaido, Japan, H5N1 HPAIVs were isolated from faecal samples of ducks flying from their nesting lakes in Siberia. Since then, in Japan, H5N1 HPAIVs have been isolated from 63 wild birds in 17 prefectures and caused HPAI outbreaks in 24 chicken farms in nine prefectures by the end of March in 2011. Each of these isolates was genetically closely related to the HPAIV isolates at Lake Ohnuma, and those in China, Mongolia, Russia and Korea, belonging to genetic clade 2.3.2.1. In addition, these isolates were genetically classified into three groups, suggesting that the viruses were transmitted by migratory water birds through at least three different routes from their northern territory to Japan. These isolates were antigenic variants, which is consistent with selection in poultry under the immunological pressure induced by vaccination. To prevent the perpetuation of viruses in the lakes where water birds nest in summer in Siberia, prompt eradication of HPAIVs in poultry is urgently needed in Asian countries where HPAI has not been controlled.