Adverse and beneficial secondary effects of mass treatment with azithromycin to eliminate blindness due to trachoma in Nepal
Adverse and beneficial secondary effects of mass treatment with azithromycin to eliminate blindness due to trachoma in Nepal
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DOI：
10.1086/341414
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发表时间：
2002-08-15
影响因子：
11.8
通讯作者：
Dowell, SF
中科院分区：
文献类型：
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作者：
Fry, AM;Jha, HC;Dowell, SF
大规模使用阿奇霉素以消除沙眼导致的失明，引起了人们对抗生素耐药性的担忧。在2000年期间，我们比较了在尼泊尔458名儿童中大规模使用阿奇霉素前后恢复的鼻咽肺炎球菌分离株的耐药性以及脓疱病、呼吸道症状和腹泻的患病率。除4.3%在2次大规模治疗中接受阿奇霉素治疗的儿童外，未分离出阿奇霉素耐药肺炎球菌（P
Mass administration of azithromycin to eliminate blindness due to trachoma has raised concerns regarding the emergence of antimicrobial resistance. During 2000, we compared the antimicrobial resistance of nasopharyngeal pneumococcal isolates recovered from and the prevalence of impetigo, respiratory symptoms, and diarrhea among 458 children in Nepal before and after mass administration of azithromycin. No azithromycin-resistant pneumococci were isolated except from 4.3% of children who had received azithromycin during 2 previous mass treatments (P