COPII-coated vesicles: flexible enough for large cargo?
COPII-coated vesicles: flexible enough for large cargo?
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DOI：
10.1016/j.ceb.2005.06.004
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发表时间：
2005-08-01
影响因子：
7.5
通讯作者：
Schekman, R
中科院分区：
文献类型：
--
作者：
Fromme, JC;Schekman, R
离开内质网前往高尔基体的货物蛋白通常携带在由 COPII 蛋白外壳包围的 60-70 nm 囊泡中。特殊哺乳动物细胞中的一些分泌货物组件太大，无法在此类载体中运输。最近对 I 型前胶原和乳糜微粒运输的研究就 CON 蛋白在这些大型生物组装体的 ER 出口中的作用得出了相互矛盾的结论。毫无疑问，COPII 对于体内的这种运输至关重要，但目前尚不清楚 COPII 是否包裹着大货物周围的膜，或者在运输载体的生物合成中发挥了更间接的作用。
Cargo proteins exiting the endoplasmic reticulum en route to the Golgi are typically carried in 60-70 nm vesicles surrounded by the COPII protein coat. Some secretory cargo assemblies in specialized mammalian cells are too large for transport within such carriers. Recent studies on procollagen-I and chylomicron trafficking have reached conflicting conclusions regarding the role of CON proteins in ER exit of these large biological assemblies. COPII is no doubt essential for such transport in vivo, but it remains unclear whether COPII envelops the membrane surrounding large cargo or instead plays a more indirect role in transport carrier biogenesis.