Inhibition-related ERP components: Variation with modality, age, and time-on-task
Inhibition-related ERP components: Variation with modality, age, and time-on-task
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DOI：
10.1027//0269-8803.16.3.167
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发表时间：
2002-01-01
影响因子：
1.3
通讯作者：
Hohnsbein, J
中科院分区：
文献类型：
--
作者：
Falkenstein, M;Hoormann, J;Hohnsbein, J
在GO/NOGO任务中，NOGO刺激后的ERP一般在额叶中央头皮区表现为负(Nogo-)N2和随后的正(Nogo-)P3。这些成分可能分别与起反应抑制作用的不同子过程有关，即通道特异性抑制和一般抑制。在本研究中，我们调查了老化或长时间工作(“工作时间”)是否会对N_2和P_3产生影响。12名年轻受试者和12名老年受试者对视觉或听觉字母刺激进行简单的Go/Nogo任务。视觉刺激后的反应时比听觉刺激后的反应时长，老年人的反应时比年轻人的长。事件相关电位的结果显示，老年人在视觉刺激后有轻微的通道特异性抑制(N2)受损，但在听觉刺激后没有。在两种模式下，老年人的总体抑制(P3)均延迟，Go-P3和RT也是如此。因此，老年人的反应减慢似乎是决定反应或抑制的过程减慢的结果。此外，年龄似乎以不同的方式影响抑制的两个方面。没有发现任务时间的影响，这表明抑制过程对精神疲劳是相当健壮的。
In Go/Nogo tasks, the ERP after Nogo stimuli generally reveals a negativity (Nogo-)N2 and a subsequent positivity (Nogo-)P3 over fronto-central scalp regions. These components are probably related to different subprocesses serving response inhibition, namely, modality-specific and general inhibition, respectively. In the present study we investigate whether aging or prolonged work ("time-on-task") have an effect on N2 and P3. Twelve young and 12 elderly subjects performed simple Go/Nogo tasks to visual or auditory letter stimuli. Reaction times were longer after visual than after auditory stimuli, and longer in the elderly than in the young. The ERP results reveal a slight impairment of modality-specific inhibition (N2) in the elderly after visual, but not after auditory, stimuli. General inhibition (P3) was delayed in the elderly for both modalities, as was Go-P3 and RT. Hence, it appears that the response slowing of the elderly is the result of a slowing of the decision process whether to respond or to inhibit. Moreover, age appears to affect both aspects of inhibition in a different manner. No effects of time-on-task were found, which suggests that the inhibitory processes are fairly robust against mental fatigue.