THE NUCLEAR RECEPTOR STEROIDOGENIC FACTOR-1 IS ESSENTIAL FOR THE FORMATION OF THE VENTROMEDIAL HYPOTHALAMIC NUCLEUS
THE NUCLEAR RECEPTOR STEROIDOGENIC FACTOR-1 IS ESSENTIAL FOR THE FORMATION OF THE VENTROMEDIAL HYPOTHALAMIC NUCLEUS
复制标题
DOI：
10.1210/me.9.4.478
复制
发表时间：
1995-04-01
影响因子：
--
通讯作者：
PARKER, KL
中科院分区：
文献类型：
--
作者：
IKEDA, Y;LUO, XR;PARKER, KL
核受体类固醇生成因子1（SF-1）调节雄性性分化的两种必需介质雄激素和苗勒氏管抑制物质的生物合成，并且是肾上腺和性腺发育以及促性腺激素表达所需的。SF-1也在胚胎腹侧间脑中表达，随后定位于下丘脑腹内侧核，这是生殖行为的重要区域。继发于Ftz-F1基因靶向破坏而缺乏SF-1的小鼠具有正常的GnRH神经元数量和位置，但表现出严重受损的下丘脑腹内侧核结构。尽管它们的GnRH神经元明显正常，但用GnRH治疗Ftz-F1破坏的小鼠可以恢复垂体促性腺激素的表达。这些研究定义了SF-1在先前与生殖相关的离散下丘脑核中的重要作用。
The nuclear receptor steroidogenic factor 1 (SF-1) regulates the biosynthesis of the two essential mediators of male sexual differentiation, androgens and Mullerian-inhibiting substance, and is required for adrenal and gonadal development and gonadotropin expression. SF-1. is also expressed in the embryonic ventral diencephalon, subsequently localizing to the ventromedial hypothalamic nucleus, a region important for reproductive behavior. Mice lacking SF-1 secondary to targeted disruption of the Ftz-F1 gene had normal numbers and location of GnRH neurons but exhibited grossly impaired ventromedial hypothalamic nucleus structure. Despite their apparently normal GnRH neurons, treatment of Ftz-F1-disrupted mice with GnRH restored pituitary gonadotropin expression, These studies define SF-1's essential role within a discrete hypothalamic nucleus previously linked to reproduction.