Regulation of insulin exocytosis by calcium-dependent protein kinase C in beta cells.
Regulation of insulin exocytosis by calcium-dependent protein kinase C in beta cells.
复制标题
DOI：
10.1016/j.ceca.2017.07.008
复制
发表时间：
2017-11
期刊：
影响因子：
4
通讯作者：
Taraska JW
中科院分区：
文献类型：
--
作者：
Trexler AJ;Taraska JW
控制胰腺β细胞释放胰岛素有助于确保适当的血糖水平，这对人类健康至关重要。蛋白激酶 C 已被证明是这一过程的关键控制机制。葡萄糖刺激后，钙流入 β 细胞，引发含胰岛素致密核心颗粒的胞吐作用，并通过钙依赖性磷脂酶 C 介导的二酰基甘油生成激活蛋白激酶 C。激活的蛋白激酶 C 通过增强胞吐作用的钙敏感性来增强胰岛素释放，可能是通过影响两个可能相关的主要途径：1）皮质肌动蛋白网络的重组，2）关键胞吐蛋白（如 munc18、SNAP25 和突触结合蛋白）的直接磷酸化。在这里，我们回顾了目前已知的蛋白激酶 C 对这些途径的作用分子机制，以及这些作用与胞吐作用控制胰岛素释放的关系。我们确定了该领域仍存在的挑战，并提出了如何解决这些挑战的建议，以增进我们对健康和疾病中胰岛素释放调节的理解。
The control of insulin release from pancreatic beta cells helps ensure proper blood glucose levels, which is critical for human health. Protein kinase C has been shown to be one key control mechanism for this process. After glucose stimulation, calcium influx into beta cells triggers exocytosis of insulin-containing dense-core granules and activates protein kinase C via calcium-dependent phospholipase C-mediated generation of diacylglycerol. Activated protein kinase C potentiates insulin release by enhancing the calcium sensitivity of exocytosis, likely by affecting two main pathways that could be linked: 1) the reorganization of the cortical actin network, and 2) the direct phosphorylation of critical exocytotic proteins such as munc18, SNAP25, and synaptotagmin. Here, we review what is currently known about the molecular mechanisms of protein kinase C action on each of these pathways and how these effects relate to the control of insulin release by exocytosis. We identify remaining challenges in the field and suggest how these challenges might be addressed to advance our understanding of the regulation of insulin release in health and disease.
登录
查看更多内容
影响因子：
16.6
作者：
Chiang, Hsueh-Cheng;Shin, Wonchul;Zhao, Wei-Dong;Hamid, Edaeni;Sheng, Jiansong;Baydyuk, Maryna;Wen, Peter J.;Jin, Albert;Momboisse, Fanny;Wu, Ling-Gang
通讯作者：
Wu, Ling-Gang
影响因子：
3.4
作者：
de Vries, KJ;Geijtenbeek, A;Verhage, M
通讯作者：
Verhage, M
影响因子：
7.7
作者：
Barg, S;Eliasson, L;Rorsman, P
通讯作者：
Rorsman, P
影响因子：
4.1
作者：
COORE, HG;RANDLE, PJ
通讯作者：
RANDLE, PJ
影响因子：
4.8
作者：
Deeney, JT;Cunningham, BA;Berggren, PO
通讯作者：
Berggren, PO