The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species
The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species
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DOI：
10.1086/504476
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发表时间：
2006-09-01
影响因子：
11.8
通讯作者：
Paterson, David L.
中科院分区：
文献类型：
--
作者：
Paterson, David L.
对所有或几乎所有市售抗生素具有耐药性的铜绿假单胞菌或不动杆菌属的分离株目前在世界范围内普遍存在。通常，这些菌株是从重症监护室中呼吸机相关性肺炎患者中回收的。“泛耐药”菌株可定义为对推荐作为呼吸机相关性肺炎经验疗法的所有β-内酰胺和喹诺酮类抗生素均耐药的菌株。这些菌株很好地适应了医院环境-分子流行病学研究经常显示，只有1或2个克隆引起重症监护病房的爆发。然而，泛耐药菌株也可以通过抗生素的使用来选择。由于缺乏抗生素选择来治疗泛耐药菌株感染，因此有必要在特定单位、机构和国家层面加强对这些微生物的监测。
Isolates of Pseudomonas aeruginosa or Acinetobacter species that are resistant to all, or almost all, commercially available antibiotics are now prevalent worldwide. Typically, these strains are recovered from patients in intensive care units who have ventilator-associated pneumonia. "Panresistant" strains can be defined as strains that are resistant to all beta-lactam and quinolone antibiotics recommended as empirical therapy for ventilator-associated pneumonia. These strains are well adapted to the hospital environment - molecular epidemiological studies have frequently revealed that only 1 or 2 clones caused outbreaks in intensive care units. However, panresistant strains may also be selected by antibiotic use. Given the lack of antibiotic options to treat infection with panresistant strains, enhanced surveillance for these organisms is necessary at unit-specific, institutional, and national levels.