Plasma BDNF is a more reliable biomarker than erythrocyte omega-3 index for the omega-3 fatty acid enrichment of brain.
Plasma BDNF is a more reliable biomarker than erythrocyte omega-3 index for the omega-3 fatty acid enrichment of brain.
复制标题
血浆 BDNF 是比红细胞 omega-3 指数更可靠的大脑 omega-3 脂肪酸富集生物标志物。
DOI：
10.1038/s41598-020-67868-9
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发表时间：
2020
影响因子：
4.6
通讯作者：
Subbaiah,PapasaniV
中科院分区：
文献类型：
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作者：
Sugasini,Dhavamani;Yalagala,PoornaCR;Subbaiah,PapasaniV
丰富大脑DHA被认为有益于预防和治疗多种神经系统疾病，包括阿尔茨海默病。评估治疗效果的一个障碍是缺乏可靠的大脑DHA生物标志物。由于血脑屏障（BBB）上独特的转运蛋白的参与，常用的红细胞ω-3指数不适用于脑。我们最近发现，膳食溶血磷脂酰胆碱（LPC）-DHA显着增加脑DHA，这导致脑BDNF的增加。由于存在BDNF通过BBB的双向转运，我们测试了血浆BDNF可用作脑DHA富集的生物标志物的假设。我们使用不同的DHA饮食载体在大范围内改变了大鼠和小鼠的大脑DHA，并确定了大脑omega-3指数增加与血浆BDNF和红细胞指数增加之间的相关性。而脑ω-3指数的增加与血浆BDNF的增加呈正相关，与红细胞指数呈负相关。这些结果表明，血浆BDNF比红细胞指数作为评估omega-3补充剂改善脑功能的有效性的生物标志物更可靠。
Enriching brain DHA is believed to be beneficial for the prevention and treatment of several neurological diseases, including Alzheimer’s disease. An impediment in assessing the effectiveness of the treatments is the lack of a reliable biomarker for brain DHA. The commonly used erythrocyte omega-3 index is not suitable for brain because of the involvement of unique transporter at the blood brain barrier (BBB). We recently showed that dietary lysophosphatidylcholine (LPC)-DHA significantly increases brain DHA, which results in increase of brain BDNF. Since there is bidirectional transport of BDNF through the BBB, we tested the hypothesis that plasma BDNF may be used as biomarker for brain DHA enrichment. We altered the brain DHA in rats and mice over a wide range using different dietary carriers of DHA, and the correlations between the increase in brain omega-3 index with the increases in plasma BDNF and the erythrocyte index were determined. Whereas the increase in brain omega-3 index positively correlated with the increase in plasma BDNF, it negatively correlated with the erythrocyte index. These results show that the plasma BDNF is more reliable than the erythrocyte index as biomarker for assessing the effectiveness of omega-3 supplements in improving brain function.