SCHIZOSACCHAROMYCES-POMBE PAC2(+) CONTROLS THE ONSET OF SEXUAL DEVELOPMENT VIA A PATHWAY INDEPENDENT OF THE CAMP CASCADE
SCHIZOSACCHAROMYCES-POMBE PAC2(+) CONTROLS THE ONSET OF SEXUAL DEVELOPMENT VIA A PATHWAY INDEPENDENT OF THE CAMP CASCADE
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DOI：
10.1007/bf00311879
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发表时间：
1995-06-01
期刊：
影响因子：
2.5
通讯作者：
YAMAMOTO, M
中科院分区：
文献类型：
--
作者：
KUNITOMO, H;SUGIMOTO, A;YAMAMOTO, M
裂糖酵母pombe pac2基因编码235个氨基酸的蛋白质，与任何已知功能的蛋白质都不相似。过表达pac2的细胞交配和产孢能力较差。在这些细胞中，氮饥饿不能诱导编码性发育关键转录因子的ste11的表达。在不完全饥饿条件下，pac2缺陷细胞可以表达ste11并进入性发育。虽然ste11的表达主要受cAMP级联的调控，但遗传分析表明，该级联与pac2在性发育的调控中可以部分地相互补偿，两者都不是上位性的。因此，Pac2似乎通过独立于cAMP级联的信号通路控制ste11的表达。
The Schizosaccharomyces pombe pac2 gene encodes a protein of 235 amino acids not similar to any protein of known function. Cells over-expressing pac2 were poor in mating and sporulation. Expression of ste11, which encodes a key transcription factor for sexual development, was not inducible by nitrogen starvation in these cells. Cells defective in pac2 could express ste11 and enter sexual development under incomplete starvation conditions. Although expression of ste11 is regulated primarily by the cAMP cascade, genetic analysis indicated that this cascade and pac2 can partially compensate for each other in the regulation of sexual development, and that neither of them is epistatic over the other. Thus, Pac2 appears to control ste11 expression via a signaling pathway independent of the cAMP cascade.