Targeting the innate immune receptor TLR8 using small-molecule agents
Targeting the innate immune receptor TLR8 using small-molecule agents
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DOI：
10.1107/s2059798320006518
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发表时间：
2020-07-01
影响因子：
2.2
通讯作者：
Shimizu, Toshiyuki
中科院分区：
文献类型：
--
作者：
Sakaniwa, Kentaro;Shimizu, Toshiyuki
Toll 样受体 (TLR) 是启动先天免疫反应的模式识别受体。在 TLR 中，TLR8（和 TLR7）识别单链 RNA 来介导下游信号。近年来，深入的 X 射线晶体结构分析为 TLR8 与各种激动剂或拮抗剂复合物的结构提供了原子见解。在这里，回顾了配体激活和失活机制的结构知识。此外，还检查了 TLR 配体的潜在临床应用。
Toll-like receptors (TLRs) are pattern-recognition receptors that initiate innate immune responses. Among the TLRs, TLR8 (and TLR7) recognizes single-stranded RNA to mediate downstream signals. In recent years, intensive X-ray crystal structural analyses have provided atomic insights into structures of TLR8 complexed with various agonists or antagonists. Here, structural knowledge of the activation and inactivation mechanisms of the ligands is reviewed. In addition, the potential clinical applications of TLR ligands are examined.