The Design of Sulfobetaine Polymers with Thermoresponsiveness under Physiological Salt Conditions
The Design of Sulfobetaine Polymers with Thermoresponsiveness under Physiological Salt Conditions
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DOI：
10.1002/macp.201900429
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发表时间：
2020-01
影响因子：
2.5
通讯作者：
N. Morimoto;Y. Oishi;Masaya Yamamoto
中科院分区：
文献类型：
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作者：
N. Morimoto;Y. Oishi;Masaya Yamamoto
温敏聚合物在水溶液中的相分离特性使其在基础和应用方面具有很大的吸引力。一些磺基甜菜碱聚合物因其生物相容性和上临界溶解温度（UCST）型热响应性而闻名;然而，在生理盐条件下，脂肪族磺基甜菜碱聚合物的热响应性消失。含芳族阳离子的磺基甜菜碱聚合物由于强的分子间相互作用而不响应。在本研究中，设计了新的具有吡啶阳离子的磺基甜菜碱甲基丙烯酰胺，3-（4-（2-甲基丙烯酰胺基）烷基吡啶-1-基）丙烷-1-磺酸盐（PySMAAm），然后使用水溶液可逆加成-断裂链转移聚合制备均聚物。P（PySMAAm）表现出UCST-型热响应性，其通过在生理盐条件下将互聚物侧链之间的偶极-偶极相互作用取代为离子-偶极相互作用而诱导。热响应性受侧链的分子量和结构的影响。这种磺基甜菜碱聚合物可以作为生物材料，特别是用于药物递送和再生医学的有前途的工具。
Thermoresponsive polymers are attractive in terms of basics and applications because of the phase separation in aqueous solution. Some sulfobetaine polymers are known for their antifouling biocompatibility and upper critical solution temperature (UCST) type thermoresponsiveness; however, thermoresponsiveness disappears in aliphatic sulfobetaine polymers in physiological salt conditions. Aromatic cation‐containing sulfobetaine polymers are not responded because of the strong intermolecular interactions. In this study, new sulfobetaine methacrylamides with a pyridinium cation, 3‐(4‐(2‐methacrylamido)alkyl pyridinio‐1‐yl)propane‐1‐sulfonates, (PySMAAm)s, are designed and then prepared the homopolymers using aqueous reversible addition‐fragmentation chain transfer polymerization. The P(PySMAAm)s exhibited UCST‐type thermoresponsiveness that is induced by substitution of the dipole–dipole interaction between the interpolymer side chain to an ion–dipole interaction in physiological salt conditions. The thermoresponsiveness is affected by the molecular weight and structure of the side chains. Such sulfobetaine polymers can be promising tools as biomaterials especially for drug delivery and regenerative medicine.