Angiogenesis and neovascularization associated with extracellular matrix-modified porous implants
Angiogenesis and neovascularization associated with extracellular matrix-modified porous implants
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DOI：
10.1002/jbm.1253
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发表时间：
2002-02-01
期刊：
影响因子：
--
通讯作者：
Williams, SK
中科院分区：
文献类型：
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作者：
Kidd, KR;Nagle, RB;Williams, SK
刺激血管生成的治疗方法旨在加速因微血管供应不足而功能失调的组织中新血管的发育。当前研究的目标是刺激多孔生物医学植入物周围和内部的血管生成反应，例如由膨胀聚四氟乙烯（ePTFE）组成的基聚合物构建的血管移植物。与许多生物材料类似，ePTFE不会引起明显的血管生成反应，并且该材料的多孔间隙在植入后保持无血管。研究评估了致瘤细胞系804-G大鼠肾细胞在ePTFE多孔结构上和内部分泌血管生成细胞外基质的能力。使用大鼠模型来评估和比较未修饰材料和细胞外基质修饰ePTFE之间的种植体相关愈合反应。结果表明，与未经处理的ePTFE相比，基质修饰的ePTFE刺激了植入体相关组织的血管生成和ePTFE间隙内孔隙的新生血管。不溶性基质的沉积刺激血管生成反应，并具有改善医疗设备功能的潜在应用。(C) 2001约翰威利父子公司
Therapies directed toward stimulation of angiogenesis seek to accelerate the development of new blood vessels in tissues rendered dysfunctional because of an insufficient microvascular supply. The goal of the current study was the stimulation of an angiogenic response around and within porous biomedical implants, such as vascular grafts, constructed from a base polymer composed of expanded polytetrafluoroethylene (ePTFE). Similar to many biomaterial, ePTFE does not elicit a significant angiogenic response and the porous interstices of this material remain avascular after implantation. Studies were performed to evaluate the ability of a tumorigenic cell line, the 804-G rat kidney cell to secrete an angiogenic extracellular matrix on and within the porous structures of ePTFE. A rat model was used to evaluate and compare implant-associated healing responses between nonmodified materials and extracellular matrix-modified ePTFE. Results demonstrated that, in contrast to untreated ePTFE, the matrix-modified ePTFE stimulated both angiogenesis in implant-associated tissue and neovascularization of the pores within the ePTFE interstices. Deposition of an insoluble matrix stimulates an angiogenic response and has a potential application for the improvement of medical device function. (C) 2001 John Wiley & Sons, Inc.