Is there an Intrinsic Relationship between LFP Beta Oscillation Amplitude and Firing Rate of Individual Neurons in Macaque Motor Cortex?
Is there an Intrinsic Relationship between LFP Beta Oscillation Amplitude and Firing Rate of Individual Neurons in Macaque Motor Cortex?
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DOI：
10.1093/texcom/tgaa017
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发表时间：
2020
影响因子：
--
通讯作者：
Kilavik BE
中科院分区：
文献类型：
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作者：
Confais J;Malfait N;Brochier T;Riehle A;Kilavik BE
运动皮层局部场电位（LFP）β振荡的特性已被广泛研究。还讨论了它们与局部神经元尖峰活动的关系。然而，β振荡的幅度和单个神经元的放电率之间是否存在内在关系仍然存在争议。一些研究表明，尖峰频率映射到β振幅，而其他人没有发现系统的关系。为了帮助解决这一争议，我们在猕猴运动皮层中量化了视觉行为过程中β振幅和神经元尖峰计数之间的相关性。首先，在一项名为“任务相关性”的分析中，包括了在所有试验时期获得的单次试验数据。这些相关性在高达32%的情况下是显著的，并且通常很强。然而，重组来自不同试验的β振幅和尖峰计数的试验洗牌控制分析揭示了这些与任务相关的相关性，以反映2个信号与任务的系统但独立的调制。第二，在一项名为“试验间相关性”的分析中，仅包括来自固定试验时期的数据，并计算试验间的相关性。试验与试验之间的相关性很弱，很少有显著性。我们的结论是，有没有内在的关系，个别神经元的放电率和LFP β振荡幅度在猕猴运动皮层。
The properties of motor cortical local field potential (LFP) beta oscillations have been extensively studied. Their relationship to the local neuronal spiking activity was also addressed. Yet, whether there is an intrinsic relationship between the amplitude of beta oscillations and the firing rate of individual neurons remains controversial. Some studies suggest a mapping of spike rate onto beta amplitude, while others find no systematic relationship. To help resolve this controversy, we quantified in macaque motor cortex the correlation between beta amplitude and neuronal spike count during visuomotor behavior. First, in an analysis termed “task-related correlation”, single-trial data obtained across all trial epochs were included. These correlations were significant in up to 32% of cases and often strong. However, a trial-shuffling control analysis recombining beta amplitudes and spike counts from different trials revealed these task-related correlations to reflect systematic, yet independent, modulations of the 2 signals with the task. Second, in an analysis termed “trial-by-trial correlation”, only data from fixed trial epochs were included, and correlations were calculated across trials. Trial-by-trial correlations were weak and rarely significant. We conclude that there is no intrinsic relationship between the firing rate of individual neurons and LFP beta oscillation amplitude in macaque motor cortex.