Analgesic effects of NB001 on mouse models of arthralgia.
Analgesic effects of NB001 on mouse models of arthralgia.
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NB001对关节痛小鼠模型的镇痛作用
DOI：
10.1186/s13041-015-0151-9
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发表时间：
2015-10-09
期刊：
影响因子：
3.6
通讯作者：
Liu SB
中科院分区：
文献类型：
--
作者：
Tian Z;Wang DS;Wang XS;Tian J;Han J;Guo YY;Feng B;Zhang N;Zhao MG;Liu SB
我们以前的研究已经证明了钙刺激腺苷酸环化酶1（AC 1）在慢性疼痛的中枢神经系统中的关键作用。在本研究中，我们研究了NB 001，AC 1的选择性抑制剂，对动物模型的踝关节关节炎和膝关节炎完全弗氏佐剂注射诱导的镇痛作用。NB 001治疗对关节水肿、僵硬和关节破坏没有影响。此外，治疗未能减弱关节炎的疾病进展。然而，NB 001治疗（3 mg/kg）显著减弱了踝关节关节炎和膝关节炎小鼠模型中的关节疼痛相关行为。结果表明，NB 001对关节炎动物模型表现出镇痛作用，但不是由抗炎活性引起的。
Our previous studies have demonstrated the critical roles of calcium-stimulated adenylyl cyclase 1 (AC1) in the central nervous system in chronic pain. In the present study, we examined the analgesic effects of NB001, a selective inhibitor of AC1, on animal models of ankle joint arthritis and knee joint arthritis induced by complete Freund’s adjuvant injection. NB001 treatment had no effect on joint edema, stiffness, and joint destruction. Furthermore, the treatment failed to attenuate the disease progression of arthritis. However, NB001 treatment (3 mg/kg) significantly weakened joint pain-related behavior in the mouse models of ankle joint arthritis and knee joint arthritis. Results indicated that NB001 exhibited an analgesic effect on the animal models of arthritis but was not caused by anti-inflammatory activities.