Geometric characterization of patient-specific total cavopulmonary connections and its relationship to hemodynamics.
Geometric characterization of patient-specific total cavopulmonary connections and its relationship to hemodynamics.
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DOI：
10.1016/j.jcmg.2013.12.010
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发表时间：
2014-03
影响因子：
14
通讯作者：
Yoganathan, Ajit P.
中科院分区：
文献类型：
--
作者：
Beng, Elaine Tang;Restrepo, Maria;Haggerty, Christopher M.;Mirabella, Lucia;Bethel, James;Whitehead, Kevin K.;Fogel, Mark A.;Yoganathan, Ajit P.
全腔静脉-肺动脉连接术(TCPC)的几何构型有很大的变异性。几何特征，如直径、连接角和容器之间的距离，被假设为影响连接内的能量和流动动力学。本研究旨在找出影响TCPC血流动力学的重要几何特征。从心脏磁共振图像(MRI)重建108例患者的解剖结构，并分析其几何特征。血管流率由相位对比MRI计算。计算流体动力学模拟被用来量化指标化功率损失和肝脏血流分布。TCPC指数功率损失与最小Fontan径路(FP)、左、右肺动脉内径呈负相关。心指数与FP最小内径和上腔静脉(SVC)最小/最大径比值相关。肝血流分布与腔静脉偏移量、肺血流分布、FP与SVC夹角相关。这些相关性可能会对未来的连接设计和患者随访产生重要影响。
Total cavopulmonary connection (TCPC) geometries have great variability. Geometric features like diameter, connection angle and distance between vessels, are hypothesized to affect the energetics and flow dynamics within the connection. This study aimed to identify important geometric characteristics that can influence TCPC hemodynamics. Anatomies from 108 consecutive patients were reconstructed from cardiac magnetic resonance images (MRI) and analyzed for their geometric features. Vessel flow rates were computed from phase contrast MRI. Computational fluid dynamics simulations were carried out to quantify the indexed power loss and hepatic flow distribution. TCPC indexed power loss correlated inversely with minimum Fontan pathway (FP), left and right pulmonary arteries diameters. Cardiac index correlated with minimum FP diameter and superior vena cava (SVC) minimum/maximum diameter ratio. Hepatic flow distribution correlated with caval offset, pulmonary flow distribution, and the angle between FP and SVC. These correlations can have important implications on future connection design and patient follow-up.
影响因子：
6
作者：
Dasi, Lakshmi P.;Whitehead, Kevin;Pekkan, Kerem;de Zelicourt, Diane;Sundareswaran, Kartik;Kanter, Kirk;Fogel, Mark A.;Yoganathan, Ajit P.
通讯作者：
Yoganathan, Ajit P.
DOI：
10.1016/j.jtcvs.2008.04.036
发表时间：
2009-03-01
影响因子：
6
作者：
Dasi, Lakshmi P.;Rema, Resmi Krishnankutty;Yoganathan, Ajit P.
通讯作者：
Yoganathan, Ajit P.