ALBUMIN LEVELS AS A PREDICTOR OF MORTALITY IN THE HEALTHY ELDERLY
ALBUMIN LEVELS AS A PREDICTOR OF MORTALITY IN THE HEALTHY ELDERLY
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DOI：
10.1016/0895-4356(92)90080-7
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发表时间：
1992-03-01
影响因子：
7.2
通讯作者：
EDELSTEIN, SL
中科院分区：
文献类型：
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作者：
KLONOFFCOHEN, H;BARRETTCONNOR, EL;EDELSTEIN, SL
血清白蛋白水平可能预测老年人随后的死亡率，但尚不清楚这是否与疾病无关。对居住在加州Rancho Bernardo的2342名年龄在50-89岁之间的健康非住院男性和女性进行的3年前瞻性研究证实了以下发现。血清白蛋白水平随着年龄的增长而下降，男性和女性，这种关联是独立的健康状况。此外，在调整年龄、性别和生活方式因素（如吸烟、运动和饮酒）后，白蛋白每降低一个标准差，死亡的相对几率为1.24（p = 0.04）。将研究样本分为在基线时报告疾病和未报告疾病的人群并没有明显改变这些结果。老年人（70-89岁）的大多数白蛋白水平在年轻人（50-69岁）的正常和狭窄范围内，然而，白蛋白水平预测的结果与已知疾病无关。白蛋白与早期死亡率的相关性表明，血清白蛋白水平是健康老年人亚临床疾病的预测因子。
Serum albumin levels probably predict subsequent mortality in the elderly, but it is not clear whether this is independent of disease. A 3 year prospective study of 2342 healthy non-institutionalized men and women aged 50-89 years old, residing in Rancho Bernardo, California, confirmed the following findings. Serum albumin levels decreased with increasing age in both men and women, and this association was independent of health status. In addition, for every standard deviation decrease in albumin, the relative odds of dying was 1.24 (p = 0.04), after adjusting for age, sex and lifestyle factors such as smoking, exercise and alcohol consumption. Separating the study sample into those who did and did not report disease at baseline did not appreciably alter these findings. Most of the albumin levels of the older adults (70-89) fall within the normal and narrow range of the younger adults (50-69), nevertheless, albumin levels predict outcome independent of known disease. The albumin-early mortality association suggests that serum albumin levels are a predictor for subclinical disease in the healthy elderly.