DIVERSITY IN MAMMALIAN TACHYKININ PEPTIDERGIC NEURONS - MULTIPLE PEPTIDES, RECEPTORS, AND REGULATORY MECHANISMS
DIVERSITY IN MAMMALIAN TACHYKININ PEPTIDERGIC NEURONS - MULTIPLE PEPTIDES, RECEPTORS, AND REGULATORY MECHANISMS
复制标题
DOI：
10.1096/fasebj.4.6.1969374
复制
发表时间：
1990-04-01
期刊：
影响因子：
4.8
通讯作者：
BANNON, MJ
中科院分区：
文献类型：
--
作者：
HELKE, CJ;KRAUSE, JE;BANNON, MJ
速激肽包括参与调节多种生物过程的密切相关的肽家族。速激肽肽P物质、神经激肽A、神经激肽A（3 - 10）、神经肽K和神经肽γ是由单个前速激肽原基因通过差异RNA剪接和差异翻译后加工产生的。另一种速激肽，神经激肽B，由单独的前速激肽原基因产生。这些前速激肽原mRNA和肽产物在整个神经系统中有差异地分布。这些速激肽肽存在三种不同的G蛋白偶联速激肽受体。这三种受体与速激肽肽的相互作用不同，并且独特地分布在整个神经系统中。NK-1受体优先与P物质相互作用，NK-2受体优先与神经激肽A、神经肽K和神经肽γ相互作用，NK-3受体与神经激肽B相互作用最好。速激肽肽能神经元系统的作用的例子取自脊髓感觉系统和黑质纹状体锥体外系运动系统。多种速激肽肽系统的功能意义，受体-第二信使偶联机制，以及肽mRNA和受体表达的发育和调控机制的分析代表了当前和未来的研究领域。赫尔克角J.道：Krause，J. E.; Mantyh，P. W.; Couture，R.; Bannon，M. J.哺乳动物速激肽肽能神经元的多样性：多种肽、受体和调节机制.FASEB J.4：1606 - 1615; 1990.
The tachykinins comprise a family of closely related peptides that participate in the regulation of diverse biological processes. The tachykinin peptides substance P, neurokinin A, neurokinin A(3‐10), neuropeptide K, and neuropeptide γ are produced from a single preprotachykinin gene as a result of differential RNA splicing and differential posttranslational processing. Another tachykinin, neurokinin B, is produced from a separate preprotachykinin gene. These preprotachykinin mRNAs and peptide products are differentially distributed throughout the nervous system. Three distinct G protein‐coupled tachykinin receptors exist for these tachykinin peptides. The three receptors interact differentially with the tachykinin peptides and are uniquely distributed throughout the nervous system. The NK‐1 receptor preferentially interacts with substance P, the NK‐2 receptor prefers neurokinin A, neuropeptide K, and neuropeptide γ, and the NK‐3 receptor interacts best with neurokinin B. Examples of the roles of tachykinin peptidergic neuronal systems are taken from the spinal cord sensory system and the nigrostriatal extrapyramidal motor system. Analysis of the functional significance of multiple tachykinin peptide systems, receptor‐second messenger coupling mechanisms, and developmental and regulatory mechanisms underlying peptide mRNA and receptor expression represent areas of current and future investigation.—Helke, C. J.; Krause, J. E.; Mantyh, P. W.; Couture, R.; Bannon, M. J. Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms.FASEB J.4: 1606‐1615; 1990.