Quantification of pancreatic exocrine function with secretin-enhanced magnetic resonance cholangiopancreatography:: normal values and short-term effects of pancreatic duct drainage procedures in chronic pancreatitis.: Initial results
Quantification of pancreatic exocrine function with secretin-enhanced magnetic resonance cholangiopancreatography:: normal values and short-term effects of pancreatic duct drainage procedures in chronic pancreatitis.: Initial results
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DOI：
10.1007/s00330-005-2819-5
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发表时间：
2005-10-01
影响因子：
5.9
通讯作者：
Matos, C
中科院分区：
文献类型：
--
作者：
Bali, M;Sztantics, A;Matos, C
本研究的目的是应用S动态胰泌素增强磁共振胆胰管成像技术对正常人和慢性胰腺炎患者胰管引流术前后的胰腺外分泌功能进行定量研究。用胰腺流量输出量(PFO)和总排泄量(TEV)对10名健康志愿者和20例CP患者(18例重度，1例中度，1例轻度)治疗前后的胰腺外分泌进行了两次定量。PFO和TEV由MR计算的体积和时间之间的线性回归得出。在所有受试者中，在分泌素刺激期间，胰腺外分泌液容量最初随时间线性增加。对照组平均PFO和TEV分别为6.8ml/min和97ml，个体内偏差分别为0.8ml/min和16ml，10/20例治疗前外分泌受损患者治疗后PFO和TEV显著升高(P<；0.05)，3/20例术后出现急性胰腺炎，PFO降低。本研究中使用的S-MRCP定量方法是可重复性的，并提供了PfO和TEV的正常值，在先前发表的插管研究中获得的值范围内。在CP患者中的初步结果已经无创地证明了PDDP后PFO和TEV的短期显着改善。
The aim of this study was to quantify pancreatic exocrine function in normal subjects and in patients with chronic pancreatitis (CP) before and after pancreatic duct drainage procedures (PDDP) with dynamic secretin-enhanced magnetic resonance (MR) cholangiopancreatography (S-MRCP). Pancreatic exocrine secretions [quantified by pancreatic flow output (PFO) and total excreted volume (TEV)] were quantified twice in ten healthy volunteers and before and after treatment in 20 CP patients (18 classified as severe, one as moderate, and one as mild according to the Cambridge classification). PFO and TEV were derived from a linear regression between MR-calculated volumes and time. In all subjects, pancreatic exocrine fluid volume initially increased linearly with time during secretin stimulation. In controls, the mean PFO and TEV were 6.8 ml/min and 97 ml; intra-individual deviations were 0.8 ml/min and 16 ml. In 10/20 patients with impaired exocrine secretions before treatment, a significant increase of PFO and TEV was observed after treatment (P < 0.05); 3/20 patients presented post-procedural acute pancreatitis and a reduced PFO. The S-MRCP quantification method used in the present study is reproducible and provides normal values for PFO and TEV in the range of those obtained from previous published intubation studies. The initial results in CP patients have demonstrated non-invasively a significant short-term improvement of PFO and TEV after PDDP.