Global Distribution Maps of the Leishmaniases
Global Distribution Maps of the Leishmaniases
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DOI：
10.7554/elife.02851
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发表时间：
2014-06-27
期刊：
影响因子：
7.7
通讯作者：
Hay, Simon I.
中科院分区：
文献类型：
--
作者：
Pigott, David M.;Bhatt, Samir;Hay, Simon I.
利什曼病是媒介传播的疾病，在美洲、非洲和亚洲的大部分地区广泛分布于全球。尽管构成了重大的公共卫生负担，但我们对利什曼病全球分布的了解仍然模糊，依赖于专家意见，并且空间分辨率较差。通过汇总各种来源的信息，在国家以下一级对利什曼病证据共识进行了全球评估。皮肤和内脏利什曼病发生记录数据库是根据已发表的文献、在线报告、菌株档案和 GenBank 资料编制而成。这些与一套生物学相关的环境协变量被用于增强回归树建模框架，以生成利什曼病的全球环境风险图。这些高分辨率的循证地图可以帮助指导未来的监测活动，确定疾病控制的目标区域，并为未来的负担估计工作提供信息。
The leishmaniases are vector-borne diseases that have a broad global distribution throughout much of the Americas, Africa and Asia. Despite representing a significant public health burden, our understanding of the global distribution of the leishmaniases remains vague, reliant upon expert opinion and limited to poor spatial resolution. A global assessment of the consensus of evidence for leishmaniasis was performed at a sub-national level by aggregating information from a variety of sources. A database of records of cutaneous and visceral leishmaniasis occurrence was compiled from published literature, online reports, strain archives and GenBank accessions. These, with a suite of biologically relevant environmental covariates, were used in a boosted regression tree modelling framework to generate global environmental risk maps for the leishmaniases. These high-resolution evidence-based maps can help direct future surveillance activities, identify areas to target for disease control and inform future burden estimation efforts.