Is ADHD severity in adults associated with the lifetime prevalence of comorbid depressive episodes and anxiety disorders?
Is ADHD severity in adults associated with the lifetime prevalence of comorbid depressive episodes and anxiety disorders?
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DOI：
10.1016/j.eurpsy.2012.05.002
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发表时间：
2013-06-01
影响因子：
7.8
通讯作者：
Bitter, I.
中科院分区：
文献类型：
--
作者：
Simon, V.;Czobor, P.;Bitter, I.
目的：本研究的目的是探讨ADHD的严重程度和终身患病率的共病抑郁发作和焦虑障碍的成年人与ADHD.Subjects/材料和方法：分析的基础上的数据康纳的成人ADHD评定量表（CAARS）和父母的研究成人ADHD的流行病学在17 GP的做法在布达佩斯，匈牙利。18 - 60岁的受试者被纳入筛选期（n = 3529）。在279例阳性筛选的受试者中，161例参与了临床访谈并完成了CAARS以确认诊断。我们应用了四个诊断标准：“DSM-IV”;“无发作”（DSM-IV标准，没有对发作的具体要求）;“仅症状”（DSM-IV症状标准）;和“仅减少症状”（DSM-IV症状标准，症状计数的阈值降低）。结果：除“ADHD_无发作”组外，所有受试者的ADHD严重程度与共病抑郁发作的患病率均呈显著正相关（“DSM-IV”：F[1.23] = 8.39，P = 0.0081;“无发作”：F（1.27）= 0.97，P = 0.3346;“仅症状”：F[1.55] = 30.79，P < 0.0001;“仅减少症状”：F（1.62）= 26.69，P < 0.0001）。讨论和结论：结果表明ADHD症状的严重程度与抑郁症的终生共病有关。(C)2012年Elsevier Masson SAS。All rights reserved.
Purpose: The objective of the present study was to examine the association between ADHD severity and the lifetime prevalence of comorbid depressive episodes and anxiety disorders in adults with ADHD.Subjects/materials and methods: Analyses were based on data of the Conner's Adult ADHD Rating Scale (CAARS) and a parent study examining the epidemiology of adult ADHD in 17 GP practices in Budapest, Hungary. Subjects between 18 and 60 years were included in the screening phase (n = 3529). Out of 279 positively screened subjects 161 participated in a clinical interview and completed the CAARS to confirm the diagnosis. We applied four diagnostic criteria: "DSM-IV"; "No-onset" (DSM-IV criteria without the specific requirement for onset); "Symptoms-only" (DSM-IV symptom criterion only); and "Reduced symptoms-only" (DSM-IV symptom criterion with a reduced threshold for symptom count). The MINI PLUS 5.0 was used to assess psychiatric comorbidity.Results: ADHD severity, as measured by the CAARS ADHD Index, showed a significant positive association with the prevalence of comorbid depressive episodes in all but the "ADHD_No-onset" group ("DSM-IV": F[1.23] = 8.39, P = 0.0081; "No-onset": F(1.27) = 0.97, P = 0.3346; "Symptoms-only": F[1.55] = 30.79, P < 0.0001; "Reduced symptoms-only": F(1.62) = 26.69, P < 0.0001).Discussion and conclusion: Results indicate that ADHD symptom severity increases in association with lifetime comorbidity with depression. (C) 2012 Elsevier Masson SAS. All rights reserved.