RETROSPLENIAL AMNESIA
RETROSPLENIAL AMNESIA
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DOI：
10.1093/brain/110.6.1631
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发表时间：
1987-12-01
期刊：
影响因子：
14.5
通讯作者：
WATSON, RT
中科院分区：
文献类型：
--
作者：
VALENSTEIN, E;BOWERS, D;WATSON, RT
一名39岁男子开发逆行性和顺行性遗忘出血后的动静脉畸形位于胼胝体压部附近。MRI研究显示压部以及包含压后皮质和扣带束的区域受损。穹窿位于最大损伤部位的前方和下方，但可能已受累;终纹可能未受累。已知对记忆很重要但未受损伤的结构包括海马体、丘脑和基底前脑。压后皮质接受来自下托的输入，并投射到前丘脑，从而提供海马和丘脑之间的替代路径。也许更重要的是，参与记忆的内侧颞叶结构直接通过扣带束和间接通过压后皮质的中继接收前丘脑输入。我们认为Papez回路的丘脑皮质部分在记忆中可能很重要，扣带回和压后皮质的损伤可能通过破坏这一通路而导致遗忘。
A 39-year-old man developed retrograde and anterograde amnesia following haemorrhage from an arteriovenous malformation situated near the splenium of the corpus callosum. MRI studies demonstrated damage to the splenium, and to a region containing the retrosplenial cortex and the cingulate bundle. The fornix was anterior and inferior to the site of maximal damage, but may have been involved; the stria terminalis was probably spared. Structures known to be important in memory but spared by the lesion included the hippocampus, thalamus, and basal forebrain. The retrosplenial cortex receives input from the subiculum and projects to the anterior thalamus, thus providing an alternative route between hippocampus and thalamus. Perhaps more importantly, medial temporal structures involved in memory receive anterior thalamic input directly via the cingulate bundle and indirectly through a relay in the retrosplenial cortex. We suggest that this thalamocortical portion of Papez' circuit may be important in memory, and that lesions of the cingulum and retrosplenial cortex may cause amnesia by disrupting this pathway.