Expanding the B Cell-Centric View of Systemic Lupus Erythematosus.
Expanding the B Cell-Centric View of Systemic Lupus Erythematosus.
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DOI：
10.1016/j.it.2017.02.001
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发表时间：
2017-05
影响因子：
16.8
通讯作者：
Bolland S
中科院分区：
文献类型：
--
作者：
Morawski PA;Bolland S
系统性红斑狼疮（SLE）是一种自身免疫性疾病，其特征在于B细胞中的自身耐受性的破坏和针对核自身抗原的抗体的产生。越来越多的证据支持这样的观点，即除了B细胞之外，其他细胞贡献者对狼疮发病机制也很重要。在这篇综述中，我们考虑了最近的进展，淋巴细胞在SLE的致病和调节作用，超越IgG自身抗体的生产。我们还讨论了各种炎症效应细胞类型参与细胞因子的产生，去除自身抗原，并对自身反应性IgE抗体的反应。我们的目标是整合这些想法，以扩大目前对导致疾病进展的细胞成分的理解，并最终帮助设计新的靶向治疗方法。
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by a breakdown of self-tolerance in B cells and production of antibodies against nuclear self-antigens. Increasing evidence supports the notion that additional cellular contributors beyond B cells are important for lupus pathogenesis. In this Review, we consider recent advances regarding both pathogenic and regulatory roles of lymphocytes in SLE, beyond the production of IgG autoantibodies. We also discuss various inflammatory effector cell types involved in cytokine production, removal of self-antigens, and responses to autoreactive IgE antibodies. We aim to integrate these ideas to expand the current understanding of the cellular components that contribute to disease progression and ultimately help in the design of novel targeted therapeutics.