Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy.
Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy.
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DOI：
10.3390/ijms22031239
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发表时间：
2021-01-27
影响因子：
5.6
通讯作者：
González-Bayón L
中科院分区：
文献类型：
--
作者：
Zaballos M;Power M;Canal-Alonso MI;González-Nicolás MÁ;Vasquez-Jimenez W;Lozano-Lominchar P;Cabrerizo-Torrente P;Palencia-García N;Gago-Quiroga S;Ginel-Feito MD;Jiménez C;Lázaro A;González-Bayón L
顺铂是肿瘤学中最广泛使用的化学治疗剂之一，尽管其肾毒性限制了应用和剂量。我们提出了一项临床研究的结果，预防顺铂引起的肾毒性的腹膜癌患者进行细胞减灭术和热腹腔内化疗（HIPEC顺铂）。采用亚胺培南/西司他丁进行预防。西司他丁是近端肾小管细胞中肾脱氢肽酶I的选择性抑制剂，可减轻顺铂的肾毒性。不幸的是，西司他丁目前没有单独上市，只能与亚胺培南联合给药。该研究有一个回顾性部分，作为对照（n = 99例接受标准手术预防的患者）和一个前瞻性部分，对应于研究组（n = 85例患者）的亚胺培南/西司他丁预防。在两组中，我们收集了关于术前肾损伤风险因素、液体管理、血流动力学控制和手术期间尿量（包括热化疗灌注）的具体数据，以及术后前7天的血流动力学和肾功能数据。该研究的主要发现是西司他丁可能对接受细胞减灭术和热腹腔内顺铂灌注的腹膜癌转移患者发挥肾保护作用。credibility值仍低于对照组（ANOVA检验，p = 0.037）。这意味着这些患者在术后更容易管理，重症监护室（ICU）和住院时间明显缩短。
Cisplatin is one of the most widely used chemotherapeutic agents in oncology, although its nephrotoxicity limits application and dosage. We present the results of a clinical study on prophylaxis of cisplatin-induced nephrotoxicity in patients with peritoneal carcinomatosis undergoing cytoreduction and hyperthermic intraperitoneal intraoperative chemotherapy (HIPEC-cisplatin). Prophylaxis was with imipenem/cilastatin. Cilastatin is a selective inhibitor of renal dehydropeptidase I in the proximal renal tubule cells that can reduce the nephrotoxicity of cisplatin. Unfortunately, cilastatin is not currently marketed alone, and can only be administered in combination with imipenem. The study has a retrospective part that serves as a control (n = 99 patients receiving standard surgical prophylaxis) and a prospective part with imipenem/cilastatin prophylaxis corresponding to the study group (n = 85 patients). In both groups, we collected specific data on preoperative risk factors of renal damage, fluid management, hemodynamic control, and urine volume during surgery (including the hyperthermic chemotherapy perfusion), as well as data on hemodynamic and renal function during the first seven days after surgery. The main finding of the study is that cilastatin may exert a nephroprotective effect in patients with peritoneal carcinomatosis undergoing cytoreduction and hyperthermic intraperitoneal cisplatin perfusion. Creatinine values remained lower than in the control group (ANOVA test, p = 0.037). This translates into easier management of these patients in the postoperative period, with significantly shorter intensive care unit (ICU) and hospital stay.
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急性肾脏损伤的步枪标准与重症患者的医院死亡率有关：一项队列分析。
影响因子：
15.1
作者：
Hoste, Eric A. J.;Clermont, Gilles;Kersten, Alexander;Venkataraman, Ramesh;Angus, Derek C.;De Bacquer, Dirk;Kellum, John A.
通讯作者：
Kellum, John A.
影响因子：
45.3
作者：
Elias, Dominique;Gilly, Francois;Glehen, Olivier
通讯作者：
Glehen, Olivier
DOI：
10.1124/jpet.110.165779
发表时间：
2010-08-10
影响因子：
3.5
作者：
Camano, Sonia;Lazaro, Alberto;Tejedor, Alberto
通讯作者：
Tejedor, Alberto
影响因子：
3.7
作者：
Canda, Aras Emre;Sokmen, Selman;Fuzun, Mehmet
通讯作者：
Fuzun, Mehmet
影响因子：
2.9
作者：
Cashin, P. H.;Ehrsson, H.;Mahteme, H.
通讯作者：
Mahteme, H.