Degradation of porous poly(D,L-lactic-co-glycolic acid) films based on water diffusion
Degradation of porous poly(D,L-lactic-co-glycolic acid) films based on water diffusion
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DOI：
10.1002/jbm.a.30980
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发表时间：
2007-03-15
影响因子：
4.9
通讯作者：
Yang, Da-Zhi
中科院分区：
文献类型：
--
作者：
Huang, Ying-Ying;Qi, Min;Yang, Da-Zhi
聚(D,L-乳酸-乙醇酸)由于其良好的生物相容性、生物可降解性和机械强度而被广泛用作药物递送的控释载体。系统地研究了致密和多孔薄膜在37℃的汉克模拟体液中长达17周的降解行为的影响。通过测量重量、分子量及其分布、形态、成分等的变化来研究薄膜的降解。特别的是，致密和多孔结构薄膜中水扩散的差异导致了不同的降解行为。根据薄膜各种性能的特征变化，建议降解过程大致分为四个阶段，暂定为吸水阶段、分子量急剧损失或形成微孔阶段、失重或形成孔扩大阶段、孔减少或孔塌陷阶段。 (c) 2006 年 Wiley 期刊公司。
Poly(D,L-lactic-co-glycolic acid) has been extensively used as a controlled release carrier for drug delivery due to its good biocompatibility, biodegradability, and mechanical strength. Effects of dense and porous film's degradation behavior have been systematically investigated up to 17 weeks in Hank's Simulated Body Fluid at 37 degrees C. The degradation of the films was studied by measuring changes in weight, molecular weight and its distribution, morphology, composition etc.. A special thing was that the differences in water diffusion in dense and porous structure films caused the different degradation behavior. According to the characteristic changes of various properties of films, the degradation process is suggested to be roughly divided into four stages, tentatively named as water absorption stage, dramatic loss of molecular weight or micro-pores formed stage, loss of weight or enlarged-pores formed stage, pores diminished or pores collapse stage. (c) 2006 Wiley Periodicals, Inc.