Remodeling endogenous H2S microenvironment in colon cancer to enhance chemodynamic therapy
Remodeling endogenous H2S microenvironment in colon cancer to enhance chemodynamic therapy
复制标题
重塑结肠癌内源性 H2S 微环境以增强化学动力学治疗
DOI：
10.1016/j.cej.2021.130098
复制
发表时间：
2021-05-06
影响因子：
15.1
通讯作者：
Tian, Qiwei
中科院分区：
文献类型：
--
作者：
Liu, Donglin;Liu, Mengjun;Tian, Qiwei
化学动力学疗法（CDT）是一种新兴的微创治疗方法，具有选择性高、副作用少、临床应用前景好等优点。然而，CDT不能有效地抑制结肠癌的生长，结肠癌由于H2S的高内源性表达而具有强烈减少的肿瘤微环境。为了克服这一局限性，提出了一种新的策略，通过CuFe2O4纳米颗粒耗尽内源性H2S来重塑微环境，从而增强结肠癌的CDT。在H2S耗尽后，CuFe2O4颗粒中Cu（II）和Fe（III）的价态被还原为Cu（I）和Fe（II），并且纳米颗粒的光热性能被激活，这两种效应都增强了CDT。此外，在体外和体内的结果表明，内源性H2S消耗CuFe2O4颗粒诱导三种效果，协同增强CDT的性能。在这项研究中，一个新的策略，以提高结肠癌的CDT的发展报告。
Chemodynamic therapy (CDT) is a newly emerged, minimally invasive treatment with high selectivity, few side effects, and good prospects for clinical application. However, CDT does not effectively inhibit the growth of colon cancer, which has a strongly reducing tumor microenvironment owing to a high endogenous expression of H2S. To overcome this limitation, a new strategy is proposed to enhance the CDT of colon cancer by remodeling the microenvironment through depletion of endogenous H2S by CuFe2O4 nanoparticles. After H2S depletion, the valence of Cu (II) and Fe (III) in CuFe2O4 particles is reduced to Cu (I) and Fe (II) and photothermal properties of the nanoparticles are activated, both these effects enhance CDT. Further, in vitro and in vivo results demonstrate that endogenous H2S depletion by CuFe2O4 particles induced three effects that synergistically enhanced the performance of CDT. In this study, the development of a new strategy to enhance the CDT of colon cancer is reported.