Toxoplasma gondii infection and schizophrenia: A case control study in a low Toxoplasma seroprevalence Mexican population
Toxoplasma gondii infection and schizophrenia: A case control study in a low Toxoplasma seroprevalence Mexican population
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DOI：
10.1016/j.parint.2010.12.003
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发表时间：
2011-06-01
影响因子：
1.9
通讯作者：
Dubey, Jitender P.
中科院分区：
文献类型：
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作者：
Alvarado-Esquivel, Cosme;David Urbina-Alvarez, Jesus;Dubey, Jitender P.
关于弓形虫感染与人类精神分裂症之间的关系，有相互矛盾的报告。因此，我们确定了这种关联在墨西哥人口的梅斯蒂索民族。通过病例对照研究设计，50名精神分裂症患者和150名对照受试者按性别、年龄、居住地和种族匹配，用酶联免疫测定法检测弓形虫IgG抗体和弓形虫IgM抗体的存在和水平。精神分裂症患者在墨西哥杜兰戈市的一家公立精神病院接受治疗，对照组由同一城市的普通人群组成。还获得了研究对象的社会人口学、临床和行为特征。精神分裂症患者血清弓形虫IgG抗体阳性率（10/50;20%）高于对照组（8/150;5.3%）（OR=4.44; 95% CI: 1.49 ~ 13.37； P=0.003）。IgG刚地弓形虫水平高于150 IU/ml的患者比对照组更常见（分别为10%对2%，P=0.02）。2例新近诊断为精神分裂症的患者中有1例（50%）有弓形虫IgM抗体，对照组中没有一例（P=0.01）。清扫猫粪史和单纯性精神分裂症（ICD-10分类：F20.6）患者的弓形虫血清阳性率显著高于无上述特征的患者（P=0.005） （P=0.03）。单纯性精神分裂症患者弓形虫血清阳性率（F20.6）明显高于偏执型精神分裂症患者（F20.0） （P=0.02）。本研究为澄清弓形虫感染与精神分裂症之间的关联提供了一些有争议的信息。爱思唯尔爱尔兰有限公司出版。
There are conflicting reports concerning the association of Toxoplasma gondii infection and schizophrenia in humans. Therefore, we determined such association in a Mexican population of Mestizo ethnicity. Through a case-control study design, 50 schizophrenic patients and 150 control subjects matched by gender, age, residence place, and ethnicity were examined with enzyme-linked immunoassays for the presence and levels of T. gondii IgG antibodies and for the presence of T. gondii IgM antibodies. Schizophrenic patients attended a public psychiatric hospital in Durango City, Mexico, and the control group consisted of individuals of the general population of the same city. Socio-demographic, clinical and behavioral characteristics from the study subjects were also obtained. Both the seroprevalence and the level of T. gondii IgG antibodies were higher in schizophrenic patients (10/50; 20%) than in control subjects (8/150; 5.3%) (OR=4.44; 95% CI: 1.49-13.37; P=0.003). The IgG T. gondii levels higher than 150 IU/ml were more frequently observed in patients than in controls (10% versus 2%, respectively; P=0.02). One (50%) of the two patients with recently diagnosed schizophrenia and none of the controls had T. gondii IgM antibodies (P=0.01). T. gondii seropositivity was significantly higher in patients with a history of cleaning cat excrement (P=0.005), and suffering from simple schizophrenia (ICD-10 classification: F20.6) (P=0.03) than patients without these characteristics. Toxoplasma seroprevalence was also significantly higher in patients with simple schizophrenia (F20.6) than in those with paranoid schizophrenia (F20.0) (P=0.02). This study provides elements to clarify the controversial information on the association of T. gondii infection and schizophrenia. Published by Elsevier Ireland Ltd.