Phenotypic data in FlyBase.
Phenotypic data in FlyBase.
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DOI：
10.1093/bib/2.1.68
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发表时间：
2001-03-01
影响因子：
9.5
通讯作者：
Drysdale, R
中科院分区：
文献类型：
--
作者：
Drysdale, R
表型分析与分子遗传学相结合是将基因功能定位于基因组的有力工具。表型数据的性质是描述性的，与所研究的有机体可以呈现的突变表型的范围一样多种多样。本文讨论了FlyBase对已发表的果蝇表型数据进行系统化的机制，并介绍了可用于数据挖掘的查询工具。尽管FlyBase是果蝇特有的，但在设计捕获、存储和报告数据的协议时面临的问题，是任何有兴趣利用表型数据最大限度地发挥基因组分析潜力的数据库所面临的问题。
Phenotypic analysis combined with molecular genetics is a powerful tool for mapping gene function onto the genome. Phenotypic data are, by their nature, descriptive, and as varied as the range of mutant phenotypes that can be presented by the organism under study. This paper discusses the mechanisms FlyBase has implemented to systematise published phenotypic data about Drosophila, and provides an introduction to the query tools available for the mining of the data. Though FlyBase is specific to Drosophila, the issues faced in devising protocols for capturing, storing and reporting data are the same issues faced by any database with an interest in using phenotypic data to maximise the potential of genomic analysis.