Slight increase in urinary albumin excretion within the normal range predicts incident hypertension in a community-based Japanese population: the Takahata study
Slight increase in urinary albumin excretion within the normal range predicts incident hypertension in a community-based Japanese population: the Takahata study
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DOI：
10.1038/hr.2014.117
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发表时间：
2015-01-01
影响因子：
5.4
通讯作者：
Kubota, Isao
中科院分区：
文献类型：
--
作者：
Hirayama, Atsushi;Konta, Tsuneo;Kubota, Isao
最近的研究表明，尿白蛋白排泄在正常范围内的高预测高血压。然而，在一般日本人群中，尿白蛋白排泄与高血压事件之间的关系尚不清楚。为了阐明这种关系，我们在412名血压正常、无糖尿病和肾功能不全的社区人群中进行了一项队列研究，并使用基线时的尿白蛋白/肌酐比值（UACR）检查了高血压的发病率。新发高血压定义为新发收缩压≥ 140 mmHg和/或舒张压≥ 90 mmHg和/或使用抗高血压药物。在随访期间（中位数，6.7年），133例受试者（32.3%）新发高血压。高血压的发生率随着基线UACR的增加而增加（UACR为20.4
Recent studies have suggested that urine albumin excretion in the high normal range predicts hypertension. However, the relationship between urinary albumin excretion in spot urine and incident hypertension remains unclear in the general Japanese population. To clarify this relationship, we conducted a cohort study in a community-based population of 412 normotensive individuals without diabetes and renal insufficiency and examined the incidence of hypertension using the urinary albumin-to-creatinine ratio (UACR) at baseline. Incident hypertension was defined as new-onset systolic blood pressure >= 140mmHg and/or diastolic blood pressure >= 90mmHg and/or the use of anti-hypertensive drugs. During the follow-up period (median, 6.7 years), 133 subjects (32.3%) newly developed hypertension. The incidence of hypertension increased with an increase in baseline UACR (20.4% for UACR