Bibliometric Analysis of the Inflammasome and Pyroptosis in Brain.
Bibliometric Analysis of the Inflammasome and Pyroptosis in Brain.
复制标题
脑炎症小体和焦亡的文献计量分析
DOI：
10.3389/fphar.2020.626502
复制
发表时间：
2020
影响因子：
5.6
通讯作者：
Xiong K
中科院分区：
文献类型：
--
作者：
Chen Y;Li Y;Guo L;Hong J;Zhao W;Hu X;Chang C;Liu W;Xiong K
背景资料：鉴于炎性小体/炎性细胞凋亡在生物学功能中的关键作用，本文采用文献计量学的方法，从Web of Science（WOS）Core数据库中检索了近20年来与脑相关的炎性小体/炎性细胞凋亡的研究热点，并对其进行了可视化分析。方法：于2020年10月16日从WOS Core Collection中检索文献。用于WOS数据库的检索词和策略如下：#1，“焦亡”;#2，“焦亡”;#3，“炎性小体”;#4，“焦亡小体”;#5“脑”;#6，“#1”OR“#2”OR“#3”OR“#4”;#7，“#5”AND“#6”。我们选择了2000年至2020年以英文发表的文章和评论。采用VOSviewer 1.6.15和CiteSpace 5.7进行可视化分析和统计学分析。R2.结果：共收集文献1,222篇。在自首次提出焦亡以来的约20年中，自2005年以来提出了关于脑中炎性小体和焦亡的出版物。十年来，参与这项工作的年度出版物数量逐渐增加，并将在2020年继续增加。引用最多的国家是中国，有523篇文献，但美国有16，328篇文献。最有影响力的作者是胡安巴勃罗德里韦罗瓦卡里与27个文件谁在迈阿密大学工作。文献计量学分析表明，炎性小体/焦亡涉及多种脑细胞类型（小胶质细胞、星形胶质细胞、神经元等），生理过程、ER应激、线粒体功能、氧化应激和疾病（创伤性脑损伤、中风、阿尔茨海默病和帕金森病）。结论：脑内炎性小体/焦亡的研究将继续成为热点。我们建议研究脑胶质细胞中参与pyroptosis和调节性细胞死亡（RCD）复杂串扰的线粒体分子的机制，这将有助于开发针对炎性小体/pyroptosis的有效治疗策略和大规模临床试验。本研究揭示了脑内炎性小体/焦亡的发展趋势和特点，为研究者进一步研究提供了有益的文献计量学分析。
Background: Considering the pivotal role of inflammasome/pyroptosis in biological function, we visually analyzed the research hotspots of inflammasome/pyroptosis related to the brain in this work through the method of bibliometrics from the Web of Science (WOS) Core database over the past two decades. Methods: Documents were retrieved from WOS Core Collection on October 16, 2020. The search terms and strategies used for the WOS database are as follow: # 1, “pyroptosis”; # 2, “pyroptotic”; # 3, “inflammasome”; # 4, “pyroptosome”; # 5 “brain”; # 6, “# 1” OR “# 2” OR “# 3” OR “# 4”; # 7, “# 5” AND “# 6”. We selected articles and reviews published in English from 2000 to 2020. Visualization analysis and statistical analysis were performed by VOSviewer 1.6.15 and CiteSpace 5.7. R2. Results: 1,222 documents were selected for analysis. In the approximately 20 years since the pyroptosis was first presented, the publications regarding the inflammasome and pyroptosis in brain were presented since 2005. The number of annual publications increased gradually over a decade, which are involved in this work, and will continue to increase in 2020. The most prolific country was China with 523 documents but the United States was with 16,328 citations. The most influential author was Juan Pablo de Rivero Vaccari with 27 documents who worked at the University of Miami. The bibliometric analysis showed that inflammasome/pyroptosis involved a variety of brain cell types (microglia, astrocyte, neuron, etc.), physiological processes, ER stress, mitochondrial function, oxidative stress, and disease (traumatic brain injuries, stroke, Alzheimer’s disease, and Parkinson’s disease). Conclusion: The research of inflammasome/pyroptosis in brain will continue to be the hotspot. We recommend investigating the mechanism of mitochondrial molecules involved in the complex crosstalk of pyroptosis and regulated cell deaths (RCDs) in brain glial cells, which will facilitate the development of effective therapeutic strategies targeting inflammasome/pyroptosis and large-scale clinical trials. Thus, this study presents the trend and characteristic of inflammasome/pyroptosis in brain, which provided a helpful bibliometric analysis for researchers to further studies.
登录
查看更多内容
炎性小呼林有助于百日咳毒素诱导的IL-1β合成，中性粒细胞血管内爬行和自身免疫性脑脊髓炎。
影响因子：
6.7
作者：
Dumas A;Amiable N;de Rivero Vaccari JP;Chae JJ;Keane RW;Lacroix S;Vallières L
通讯作者：
Vallières L
影响因子：
16.6
作者：
Flores J;Noël A;Foveau B;Lynham J;Lecrux C;LeBlanc AC
通讯作者：
LeBlanc AC
影响因子：
9.3
作者：
Cribbs DH;Berchtold NC;Perreau V;Coleman PD;Rogers J;Tenner AJ;Cotman CW
通讯作者：
Cotman CW
影响因子：
6.3
作者：
Abulafia, Denise P.;Vaccari, Juan Pablo de Rivero;Dietrich, W. Dalton
通讯作者：
Dietrich, W. Dalton
影响因子：
4.1
作者：
Adamczak S;Dale G;de Rivero Vaccari JP;Bullock MR;Dietrich WD;Keane RW
通讯作者：
Keane RW