Bacterial acidity-triggered antimicrobial activity of self-assembling peptide nanofibers
Bacterial acidity-triggered antimicrobial activity of self-assembling peptide nanofibers
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DOI：
10.1039/c9tb00134d
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发表时间：
2019-05-14
影响因子：
7
通讯作者：
Dong, He
中科院分区：
文献类型：
--
作者：
Chen, Weike;Li, Shuxin;Dong, He
开发了一种自组装的肽段，用于检测与细菌生长相关的微环境pH变化。使用近红外探针，观察到细菌菌落的局部pH值降低与肽分解程度之间存在很强的相关性，这导致它们对厌氧菌的抗微生物活性增强。
A self-assembling peptide nanofiber was developed to sense the microenvironmental pH change associated with bacterial growth. Using a near-infrared probe, a strong correlation was observed between the local pH reduction of bacterial colonies with the degree of peptide disassembly, which led to their enhanced antimicrobial activity against anaerobic bacteria.