Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions.
Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions.
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DOI：
10.4049/jimmunol.1601150
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发表时间：
2017-01-15
期刊：
影响因子：
--
通讯作者：
Kane LP
中科院分区：
文献类型：
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作者：
Phong B;Avery L;Menk AV;Delgoffe GM;Kane LP
人们越来越认识到，细胞代谢和生物能量途径在激活的白细胞中不仅仅起着被动的作用。相反，新陈代谢在控制细胞激活、分化、存活和效应器功能方面发挥着重要作用。这项工作的大部分都是在T细胞中进行的；然而，关于肥大细胞代谢重新编程及其对细胞功能的影响的信息仍然很少。肥大细胞发挥重要的屏障功能，帮助控制2型免疫反应。在这里，我们展示了小鼠骨髓来源的肥大细胞通过免疫球蛋白EFc受体(FcεRI)来响应刺激而迅速改变其代谢。我们还证明，特定的代谢途径似乎是控制肥大细胞功能的不同需要。代谢途径的调控可能代表着肥大细胞活化调控的一个新的切入点。
There is growing appreciation that cellular metabolic and bioenergetic pathways do not play merely passive roles in activated leukocytes. Rather, metabolism plays important roles in controlling cellular activation, differentiation, survival and effector function. Much of this work has been performed in T cells; however, there is still very little information regarding mast cell metabolic reprogramming and its effect on cellular function. Mast cells perform important barrier functions and help control type 2 immune responses. Here we show here that murine bone marrow derived mast cells rapidly alter their metabolism in response to stimulation through the Fc receptor for IgE (FcεRI). We also demonstrate that specific metabolic pathways appear to be differentially required for control of mast cell function. Manipulation of metabolic pathways may represent a novel point for manipulation of mast cell activation.