Accelerated cortical thinning within structural brain networks is associated with irritability in youth
Accelerated cortical thinning within structural brain networks is associated with irritability in youth
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DOI：
10.1038/s41386-019-0508-3
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发表时间：
2019-12-01
影响因子：
7.6
通讯作者：
Satterthwaite, Theodore D.
中科院分区：
文献类型：
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作者：
Jirsaraie, Robert J.;Kaczkurkin, Antonia N.;Satterthwaite, Theodore D.
易怒是精神病理学的一个重要维度，跨越多个临床诊断类别，但其与大脑发育模式的关系仍然很少探索。在这里，我们研究了易激惹的转诊症状如何与结构性大脑网络的发展相关。所有参与者（n = 137，83名女性）在两个时间点（随访时的平均年龄：21.1岁，平均扫描间隔：5.2年）完成了3特斯拉MRI脑结构成像。随访时的易怒性使用情感反应指数进行评估，皮质厚度使用高级标准化工具软件进行量化。使用非负矩阵因子分解（一种多变量分析技术）描绘结构协方差网络。采用惩罚样条广义加性模型对随访时与易怒的横截面和纵向关联进行了评价。错误发现率（q < 0.05）用于校正多重比较。对随访数据的横截面分析显示，24个协方差网络中有11个与易怒相关，易怒程度越高，皮质越薄。纵向分析进一步显示，9个网络内的加速皮质变薄与随访时的易怒有关。影响在涉及情绪调节的大脑区域特别突出，包括眶额、外侧颞叶和内侧颞叶皮层。总的来说，这些发现表明，易怒与广泛的皮质厚度减少和加速皮质变薄有关，特别是在额叶和颞叶皮质。对情绪调节重要的区域的异常结构成熟可能是易怒症状的部分基础。
Irritability is an important dimension of psychopathology that spans multiple clinical diagnostic categories, yet its relationship to patterns of brain development remains sparsely explored. Here, we examined how transdiagnostic symptoms of irritability relate to the development of structural brain networks. All participants (n = 137, 83 females) completed structural brain imaging with 3 Tesla MRI at two timepoints (mean age at follow-up: 21.1 years, mean inter-scan interval: 5.2 years). Irritability at follow-up was assessed using the Affective Reactivity Index, and cortical thickness was quantified using Advanced Normalization Tools software. Structural covariance networks were delineated using non-negative matrix factorization, a multivariate analysis technique. Both cross-sectional and longitudinal associations with irritability at follow-up were evaluated using generalized additive models with penalized splines. The False Discovery Rate (q < 0.05) was used to correct for multiple comparisons. Cross-sectional analysis of follow-up data revealed that 11 of the 24 covariance networks were associated with irritability, with higher levels of irritability being associated with thinner cortex. Longitudinal analyses further revealed that accelerated cortical thinning within nine networks was related to irritability at follow-up. Effects were particularly prominent in brain regions implicated in emotion regulation, including the orbitofrontal, lateral temporal, and medial temporal cortex. Collectively, these findings suggest that irritability is associated with widespread reductions in cortical thickness and accelerated cortical thinning, particularly within the frontal and temporal cortex. Aberrant structural maturation of regions important for emotional regulation may in part underlie symptoms of irritability.