Remarkable three-step-one-pot solution phase preparation of novel imidazolines utilizing a UDC (Ugi/de-Boc/cyclize) strategy
Remarkable three-step-one-pot solution phase preparation of novel imidazolines utilizing a UDC (Ugi/de-Boc/cyclize) strategy
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DOI：
10.1016/s0040-4039(99)01580-4
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发表时间：
1999-11-05
影响因子：
1.8
通讯作者：
Morrissette, M
中科院分区：
文献类型：
--
作者：
Hulme, C;Ma, L;Morrissette, M
This communication reveals the novel solution phase synthesis of an array of biologically relevant imidazolines in a remarkable 'three-step-one-pot' procedure, utilizing a Ugi/de-Boc/cyclization (UDC) strategy. Transformations are carried out in excellent yield by condensation of N-Boc-alpha-amino-aldehydes and supporting Ugi reagents. The described protocol represents a highly attractive solution phase procedure for the rapid generation of this class of molecule. (C) 1999 Elsevier Science Ltd. All rights reserved.
