Dieting tendency and eating behavior problems in eating disorder correlate with right frontotemporal and left orbitofrontal cortex: a near-infrared spectroscopy study.
Dieting tendency and eating behavior problems in eating disorder correlate with right frontotemporal and left orbitofrontal cortex: a near-infrared spectroscopy study.
复制标题
DOI：
10.1016/j.jpsychires.2009.11.005
复制
发表时间：
2010-06
影响因子：
4.8
通讯作者：
M. Suda;T. Uehara;M. Fukuda;Toshimasa Sato;M. Kameyama;M. Mikuni
中科院分区：
文献类型：
--
作者：
M. Suda;T. Uehara;M. Fukuda;Toshimasa Sato;M. Kameyama;M. Mikuni
额叶功能障碍是进食障碍的病理生理基础之一。在使用症状相关刺激（如食物和身体图像扭曲）的神经影像学研究中，ED的神经基质已经被检查过，但由于研究设计、任务和使用的刺激的差异，结果不一致。为了阐明额叶功能障碍与ED临床症状的相关性，我们使用近红外光谱（NIRS）检查了认知任务期间的额叶功能，而不是与症状相关的任务，近红外光谱（NIRS）由于其完全无创和自然的测量设置而适用于ED的功能神经影像学研究。使用52通道NIRS仪器监测27名女性ED患者和27名匹配的健康对照者在语言流畅性任务（字母版本）期间的局部血流动力学变化，并检查其与使用饮食态度量表（EAT-26）评估的临床症状的相关性。ED组双侧眶额区和右侧额颞区血流动力学变化明显小于对照组，且与右侧额颞区EAT-26节食倾向评分、左侧眶额区限食和暴食评分呈负相关。ED的临床症状被认为由两部分组成：与右侧额颞皮质相关的节食倾向和与左侧眶额皮质相关的饮食行为问题。
Frontal lobe dysfunctions have been implicated as one of the pathophysiological bases in eating disorder (ED). Neural substrates of ED have been examined in neuroimaging studies employing symptom-related stimuli, such as food and body-image distortion, but with inconsistent results because of differences in study design, task, and stimulus used. In order to elucidate frontal lobe dysfunction correlates of clinical symptoms in ED, we examined the frontal lobe function during a cognitive task, not a symptom-related task, using near-infrared spectroscopy (NIRS), which is suitable for the functional neuroimaging study of ED because of its complete noninvasiveness and natural measurement setting. Regional hemodynamic changes were monitored during a verbal fluency task (letter version) using a 52-channel NIRS apparatus in 27 female ED patients and 27 matched healthy controls, and their correlations with clinical symptoms assessed using the Eating Attitude Scale (EAT-26) were examined. Regional hemodynamic changes were significantly smaller in the ED group than in the control group in the bilateral orbitofrontal and right frontotemporal regions, and negatively correlated with dieting tendency scores in EAT-26 in the right frontotemporal regions and with the eating restriction and binge eating scores in the left orbitofrontal regions. The clinical symptoms of ED are considered to consist of two components: dieting tendency that correlates with the right frontotemporal cortex and eating behavior problems that correlate with left the orbitofrontal cortex.