Insulinomimetic bis(maltolato)zinc(II) complex: blood glucose normalizing effect in KK-A(y) mice with type 2 diabetes mellitus.
Insulinomimetic bis(maltolato)zinc(II) complex: blood glucose normalizing effect in KK-A(y) mice with type 2 diabetes mellitus.
复制标题
模拟胰岛素双（麦芽糖）锌（II）复合物：2 型糖尿病 KK-A(y) 小鼠的血糖正常化作用。
DOI：
10.1006/bbrc.2001.4456
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发表时间：
2001
影响因子：
3.1
通讯作者：
Y. Kojima
中科院分区：
文献类型：
--
作者：
Y. Yoshikawa;Eriko Ueda;H. Miyake;H. Sakurai;Y. Kojima
在发现用肾上腺素处理的离体大鼠脂肪细胞在抑制游离脂肪酸释放方面具有很强的体外模拟活性后，通过每天腹膜内（ip）给予锌（II）复合物双（麦芽糖）锌（II）（Zn（Mal）（2））与Zn（O（4））协调模式，使患有2型糖尿病的KK-A（y）小鼠的高血糖水平正常化。在给予Zn(Mal)(2)复合物14天期间，血糖水平维持在正常范围，并且通过口服葡萄糖耐量试验证实了葡萄糖耐量的改善。
High blood glucose levels of KK-A(y) mice with type 2 diabetes mellitus were normalized by daily intraperitoneal (ip) administration of a zinc(II) complex, bis(maltolato)zinc(II) (Zn(Mal)(2)) with a Zn(O(4)) coordination mode, following the finding of strong in vitro insulinomimetic activity in isolated rat adipocytes treated with epinephrine in terms of the inhibition of free fatty acid release. The blood glucose level was maintained in the normal range during administration of the Zn(Mal)(2) complex for 14 days and improvements in the glucose tolerance were confirmed by an oral glucose tolerance test.