An injectable anti-microbial and adhesive hydrogel for the effective noncompressible visceral hemostasis and wound repair
An injectable anti-microbial and adhesive hydrogel for the effective noncompressible visceral hemostasis and wound repair
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DOI：
10.1016/j.msec.2021.112422
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发表时间：
2021-09-15
影响因子：
7.9
通讯作者：
Wang, Shige
中科院分区：
文献类型：
--
作者：
Chen, Zheng;Wu, Hang;Wang, Shige
制备原位形成的止血水凝胶（GelMA/OD/Borax）用于紧急伤口止血和抗炎应用。以明胶为骨架，用甲基丙烯酸酐（MA）对明胶进行改性，合成了具有良好光催化聚合性能的明胶-甲基丙烯酸酐（GelMA）。通过氧化葡聚糖的邻羟基，产生与组织表面的-NH 2交联并提供组织粘附的醛基。此外，四硼酸钠与氧化葡聚糖（OD）形成动态硼酸酯键。利用这种三重网络结构，所制备的水凝胶呈现出优异的止血能力并且克服了165 mmHg的高血压，这高于健康成人的阈值收缩压（即，120 mmHg）。该水凝胶的力学性能、形态学、生物相容性和降解性均符合硼砂的特性，成功地阻断了出血，促进了伤口愈合。本研究为设计一种多功能止血水凝胶提供了一种新的模式，用于有效止血和伤口愈合。
An in-situ formed hemostatic hydrogel (GelMA/OD/Borax) was prepared for the emergency wound hemostasis and anti-inflammation applications. Gelatin was chosen as the backbone and modified with methacrylic anhydride (MA) to synthesize GelMA, which showed the admirable UV light activatable polymerizing ability. Aldehyde groups, which cross-linked with the -NH2 on the tissue surface and afforded the tissue adhesion, were produced by oxidizing the o-hydroxyl groups of dextran. Further, the sodium tetraborate formed dynamic boric acid ester bonds with the oxidized dextran (OD). With this triple-network structure, the as-prepared hydrogel presented excellent hemostatic capacity and surmounted a high blood pressure of 165 mmHg, which is higher than the threshold systolic blood pressure of healthy adults (i.e., 120 mmHg). The mechanical property, morphology, biocompatibility and degradation of the hydrogel were character Borax, the hydrogel successfully blocked the bleeding and accelerated the wound healing. This research provides a new modality for the design of a multifunctional hemostatic hydrogel for effective hemostasis and wound healing.