Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit.
Mechanisms of disturbed emotion processing and social interaction in borderline personality disorder: state of knowledge and research agenda of the German Clinical Research Unit.
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DOI：
10.1186/2051-6673-1-12
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发表时间：
2014
影响因子：
4.1
通讯作者：
Bohus M
中科院分区：
文献类型：
--
作者：
Schmahl C;Herpertz SC;Bertsch K;Ende G;Flor H;Kirsch P;Lis S;Meyer-Lindenberg A;Rietschel M;Schneider M;Spanagel R;Treede RD;Bohus M
在过去的二十年里，对边缘型人格障碍的情绪失调机制的实证研究有了很大的发展。主要的发现包括与情绪处理有关的大脑区域的结构和功能改变，如杏仁核，杏仁核和前额叶区域。此外，更具体的机制，扰乱情绪调节，例如有关疼痛和解离，已被确定。最近，社会互动问题及其潜在的神经生物学机制，例如信任障碍或对社会排斥的超敏反应，已成为BPD研究的主要焦点。本文涵盖了目前的知识和相关的相关研究目标。第一部分是文献综述。第二部分阐述了未来研究中需要解决的重要问题。第三部分介绍了一个大型德国中心赠款的研究议程，重点是情绪失调的BPD的机制。
The last two decades have seen a strong rise in empirical research in the mechanisms of emotion dysregulation in borderline personality disorder. Major findings comprise structural as well as functional alterations of brain regions involved in emotion processing, such as amygdala, insula, and prefrontal regions. In addition, more specific mechanisms of disturbed emotion regulation, e.g. related to pain and dissociation, have been identified. Most recently, social interaction problems and their underlying neurobiological mechanisms, e.g. disturbed trust or hypersensitivity to social rejection, have become a major focus of BPD research. This article covers the current state of knowledge and related relevant research goals. The first part presents a review of the literature. The second part delineates important open questions to be addressed in future studies. The third part describes the research agenda for a large German center grant focusing on mechanisms of emotion dysregulation in BPD.