Sex steroid axes in determining male predominance in hepatocellular carcinoma
Sex steroid axes in determining male predominance in hepatocellular carcinoma
复制标题
性类固醇轴决定肝细胞癌中男性的优势
DOI：
10.1016/j.canlet.2022.216037
复制
发表时间：
2023
期刊：
影响因子：
9.7
通讯作者：
Xing Wang
中科院分区：
文献类型：
--
作者：
Lei Zhang;Jinfeng Wu;Qiumei Wu;Xiangjuan Zhang;Shuaicai Lin;Wanli Ran;Zhu Li;Chengyan Tang;Xing Wang
肝细胞癌（HCC）是癌症相关死亡的第三大原因。男性肝癌发病率、预后和治疗反应的机制是复杂的，目前尚无定论。在致癌、病毒感染和免疫反应中的性别偏向分子特征已经在性激素效应的背景下被研究。本文综述了激素以性二型方式调控肝癌发展的机制。首先，雄激素/雄激素受体（AR）促进细胞增殖和病毒感染，尤其是在HCC的初始阶段，而雌激素/雌激素受体（ER）以相反的方式起作用，诱导细胞凋亡和免疫应答。有趣的是，总结了AR在晚期HCC转移中的作用的争议，其原因归因于癌症分级或实验模型之间的不一致。此外，对两性异形现象背后复杂的细胞和分子机制的新认识也进行了充分的讨论。详细了解肝癌中与性别相关的男性优势调节可能有助于在高危人群中制定个性化的治疗策略。
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. The mechanisms for male .propensity in HCC incidence, prognosis and treatment responses are complicated and remain inconclusive. Sex- .biased molecular signatures in carcinogenesis, viral infections and immune responses have been studied pre-.dominantly within the context of sex hormones effects. This review integrates current knowledge on the .mechanisms through which the hormones regulate HCC development in sexually dimorphic fashion. Firstly, the .androgen/androgen receptor (AR) accelerate cell proliferation and virus infection, especially during the initial .stage of HCC, while estrogen/estrogen receptor (ER) function in an opposite way to induce cell apoptosis and .immune responses. Interestingly, the controversial effects of AR in late stage of HCC metastasis are summarized .and the reasons are attributed to inconsistent cancer grading or experimental models between the studies. In .addition, the new insights into these intricate cellular and molecular mechanisms underlying sexual dimorphism .are fully discussed. A detailed understanding of sex hormones-associated regulation to male predominance in .HCC may help to develop personalized therapeutic strategies in high-risk populations.