CD23 expression in follicular lymphoma: clinicopathologic correlations.
CD23 expression in follicular lymphoma: clinicopathologic correlations.
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滤泡性淋巴瘤中的 CD23 表达：临床病理相关性。
DOI：
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发表时间：
2011
影响因子：
3.5
通讯作者：
S. Kroft
中科院分区：
文献类型：
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作者：
H. Olteanu;T. Fenske;A. Harrington;A. Szabo;Peng;S. Kroft
滤泡性淋巴瘤（FL）通常是一种CD 10 +/CD 5-/FMC-7+ B细胞淋巴瘤，具有可变的CD 23表达。FL中CD 23表达的临床意义尚不明确。我们研究了69例淋巴结（LN）中CD 23的表达，并将其与病理和临床参数相关联。在69例FL中，48例（70%）为CD 23+。3级FL为CD 23-的频率（12/16 [75%]）高于1级和2级病例（9/53 [17%]; P <0.001）。CD 23表达在腹股沟淋巴结的FL中比其他部位更常见：23例中有20例（87%）vs 46例中有28例（61%; P = 0.029）。CD 23+组的总生存期（P = 0.002）和无事件生存期（P <0.0001）长于CD 23-FL组。我们的研究表明，3级FL更经常是CD 23-比较低级别的FL，腹股沟淋巴结中的FL更经常是CD 23+比其他部位的淋巴结。此外，我们的研究结果还表明，CD 23 + FL的生存率明显更好。
Follicular lymphoma (FL) is typically a CD10+/CD5-/FMC-7+ B-cell lymphoma with variable CD23 expression. The clinical significance of CD23 expression in FL is uncertain. We studied the expression of CD23 by flow cytometry in 69 lymph nodes (LNs) and correlated it with pathologic and clinical parameters. Of 69 FLs, 48 (70%) were CD23+. Grade 3 FLs were CD23- more often (12/16 [75%]) than grade 1 and 2 cases (9/53 [17%]; P < .001). CD23 expression was more common in FLs in inguinal LNs than in other sites: 20 of 23 (87%) vs 28 of 46 (61%; P = .029). Overall survival (P = .002) and event-free survival (P < .0001) were longer in the CD23+ group than in the CD23- FLs. Our study shows that grade 3 FLs are more often CD23- than lower grade FLs and that FLs in inguinal LNs are more frequently CD23+ than in LNs from other sites. Furthermore, our findings also indicate that survival is significantly better in CD23+ FLs.
影响因子：
158.5
作者：
Dave, SS;Wright, G;Staudt, LM
通讯作者：
Staudt, LM