THE NORMAL BRAIN-STEM FROM INFANCY TO OLD-AGE - A MORPHOMETRIC MRI STUDY
THE NORMAL BRAIN-STEM FROM INFANCY TO OLD-AGE - A MORPHOMETRIC MRI STUDY
复制标题
DOI：
10.1007/bf00612119
复制
发表时间：
1994-07-01
期刊：
影响因子：
2.8
通讯作者：
SANTAVUORI, P
中科院分区：
文献类型：
--
作者：
RAININKO, R;AUTTI, T;SANTAVUORI, P
我们的目的是开发一种通过常规核磁共振测量脑干大小的方法，并在正常人群中确定脑干大小。我们检查了174名年龄从4个月到86岁的受试者，他们没有已知的脑部疾病。在矢状位T1加权像上测量中脑、脑桥和延髓的中线矢状径，在轴位T2加权像上测量冠状面直径。成人中脑矢状径在6岁时达到最大值，45~50岁后略有缩小。桥脑的大小在20岁以前一直在增加，此后并没有减少。延髓的中矢状径和冠中径分别在6岁和8岁时停止增长。50岁后矢状面中径缩小最小。记录每个维度的正常范围。了解脑干大小的正常变化有助于神经退行性疾病的研究。所述方法快速，不需要额外的硬件或软件。另外一个发现是50岁以上受试者的大型蠕虫沟增多。
Our purpose was to develop a method of measuring the size of the brain stem by routine MRI and to determine brain stem dimensions in a normal population. We examined 174 subjects, aged 4 months to 86 years, with no known brain disease. Sagittal midline diameters of the mesencephalon, pens and medulla oblongata were measured on sagittal T1-weighted images, coronal diameters from axial T2-weighted images. The adult midsagittal diameter of the mesencephalon was reached at the age of 6 years, and decreased slightly after 45-50 years. Pontine dimensions increased until the age of 20 years and did not subsequently decrease. The midsagittal and midcoronal diameters of the medulla oblongata stopped increasing at the ages of 6 and 8 years, respectively. Minimal reduction in the midsagittal diameter occurs after 50 years. Normal ranges for each dimension were recorded. Knowledge of the normal variation in size of the brain stem can be helpful in the investigation of neurodegenerative diseases. The method described is rapid and needs no additional hard-or software. An additonal finding was an increase in large vermian sulci in subjects over 50 years of age.